[1]张国梁,胡逸民.利用纳米颗粒的光核反应实现原位活化治疗的可行性研究[J].中国医学物理学杂志,2020,37(6):696-701.[doi:DOI:10.3969/j.issn.1005-202X.2020.06.008]
　ZHANG Guoliang,HU Yimin.Feasibility of using photo-nuclear reaction of nanoparticles to achieve in situ activation therapy[J].Chinese Journal of Medical Physics,2020,37(6):696-701.[doi:DOI:10.3969/j.issn.1005-202X.2020.06.008]
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利用纳米颗粒的光核反应实现原位活化治疗的可行性研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第6期
页码:
696-701
栏目:
医学放射物理
出版日期:
2020-06-25

文章信息/Info

Title:
Feasibility of using photo-nuclear reaction of nanoparticles to achieve in situ activation therapy
文章编号:
1005-202X（2020）06-0696-06
作者:
张国梁; 胡逸民
武汉大学物理科学与技术学院， 湖北 武汉 430072
Author(s):
ZHANG Guoliang;  HU Yimin
School of Physics and Technology, Wuhan University, Wuhan 430072, China
关键词:
光核反应; 纳米金颗粒; Geant4; 细胞模型; 物理模型
Keywords:
Keywords: photo-nuclear reaction gold nanoparticle Geant4 cell model physical model
分类号:
R318；O572.2
DOI:
DOI:10.3969/j.issn.1005-202X.2020.06.008
文献标志码:
A
摘要:
目的：利用蒙特卡罗程序Geant4模拟13.5 MeV和6 MeV X射线照射细胞内的纳米颗粒，分析其光核反应的剂量贡献份额。方法：以纳米金颗粒（GNP）为例，分别模拟6 MeV和13.5 MeV照射细胞内的GNP，给出各自条件下由GNP造成的剂量贡献。创建水模体（0.426 mm×0.426 mm×0.426 mm），包含1 103个细胞，作为GNP的载体。在6 MeV和13.5 MeV下分别模拟细胞中包含和不包含GNP所造成的剂量沉积。结果：13.5 MeV X射线照射，其由GNP造成的剂量贡献为5.12 cGy，细胞总能量沉积为25.37 cGy，由GNP引起的剂量贡献占20.19%；6 MeV X射线照射，其由GNP造成的剂量贡献为2.87 cGy，细胞总能量沉积为23.05 cGy，由GNP造成剂量贡献约为12.46%。与6 MeV相比，13.5 MeV下由GNP光核反应造成的剂量贡献占7.7%。结论：对于细胞模型内纳米金的研究表明，GNP确实能引起额外的剂量贡献。由于GNP光核反应引起的剂量贡献很低，难以作为能够被原位激活的放射源使用。
Abstract:
Abstract: Objective To simulate the nanoparticles inside the cells that are irradiated by 13.5 MeV and 6 MeV X-rays by Monte Carlo toolkit Geant4, and to explore the dose contributions coming from the nanopaticles activated by photo-nuclear reaction. Methods Taking gold nanoparticles (GNP) as the example, the situations that the GNP inside the cells were irradiated by 13.5 MeV and 6 MeV X-rays were simulated, and the dose depositions caused by GNP were studied. A water tank (0.426 mm×0.426 mm×0.426 mm) that contained 1 103 cells was taken as the container of GNP. Based on the irradiation by 6 MeV and 13.5 MeV X-rays, the dose depositions in two kinds of cell models (with and without GNP) were analyzed. Results The dose contribution of GNP irradiated by 13.5 MeV X-rays reached 5.12 cGy which was 20.19% of the total dose deposition (25.37 cGy), while the dose contribution of GNP irradiated by 6 MeV X-rays reached 2.87 cGy which was 12.46% of the total dose deposition (23.05 cGy). Compared with the dose contribution under the irradiation by 6 MeV X-rays, the dose contribution coming from GNP activated by photo-nuclear reaction under the irradiation by 13.5 MeV X-rays accounted for about 7.7%. Conclusion The study on the GNP in cell models shows that GNP does lead to additional dose depositions. Because of the low dose contribution caused by photo-nuclear reaction, it is impossible to take the GNP activated by photo-nuclear reaction as in situ activated radiation source.

备注/Memo

备注/Memo:
【收稿日期】2019-12-11 【作者简介】张国梁，硕士，研究方向：医学物理，E-mail:guoliang.zhang @whu.edu.cn
更新日期/Last Update: 2020-07-03