[1]张君席,刘振湘,张平,等. 基于太赫兹光谱和成像的前列腺癌检测[J].中国医学物理学杂志,2019,36(5):556-562.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.012]
　ZHANG Junxi,LIU Zhenxiang,ZHANG Ping,et al. Detection of prostate cancer based on terahertz spectroscopy and imaging[J].Chinese Journal of Medical Physics,2019,36(5):556-562.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.012]
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 基于太赫兹光谱和成像的前列腺癌检测()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第5期
页码:
556-562
栏目:
医学影像物理
出版日期:
2019-05-25

文章信息/Info

Title:
 Detection of prostate cancer based on terahertz spectroscopy and imaging
文章编号:
1005-202X（2019）05-0556-07
作者:
 张君席1; 刘振湘1; 张平2; 白志明1
 1.中南大学湘雅医学院附属海口医院泌尿外科， 海南 海口 570208； 2.福州大学机械工程及自动化学院， 福建 福州 350108
Author(s):
 ZHANG Junxi1;  LIU Zhenxiang1;  ZHANG Ping2;  BAI Zhiming1
 1. Department of Urinary Surgery, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China; 2. School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou 350108, China
关键词:
 ; 前列腺癌; 太赫兹光谱与成像; H-E染色; 吸收系数; 折射率
Keywords:
 ; Keywords: prostate cancer;  terahertz spectrum and imaging;  H-E staining;  absorption coefficient;  refractive index
分类号:
R318；R737.25；O433.4
DOI:
DOI:10.3969/j.issn.1005-202X.2019.05.012
文献标志码:
A
摘要:
 目的：探讨太赫兹电磁波应用于前列腺癌的诊断。方法：抽取32例前列腺癌患者的石蜡组织块，同时行H-E染色和太赫兹反射式成像检测后，根据H-E病理结果，找出前列腺组织块样本的肿瘤区域、正常前列腺组织区域、平滑肌区域，然后再对这3个区域行太赫兹透射式光谱检测。结果：反射式成像识别和H-E染色找出的肿瘤区域之间形状和面积大小都存在相关性（P<0.001）；3类组织区域透射式光谱测出的吸收系数和折射率存在显著差异（P<0.001）；肿瘤组织对太赫兹光谱的吸收系数与细胞核百分比存在相关性（P<0.001）；5组不同分级分组的肿瘤组织之间的吸收系数均存在差异（P<0.001）。结论：太赫兹成像能较准确地识别石蜡包埋的前列腺肿瘤组织轮廓；太赫兹光谱技术不仅能区分平滑肌、肿瘤和正常前列腺组织，而且还能识别不同分级分组的前列腺癌；肿瘤石蜡组织对太赫兹的光学反应与细胞核百分比有关。
Abstract:
 Abstract: Objective To investigate the application of terahertz electromagnetic waves in the diagnosis of prostate cancer. Methods The paraffin tissue mass of 32 patients with prostate cancers were extracted and detected with H-E staining and terahertz reflection imaging. According to the H-E pathological results, the tumor area, normal prostate tissue area and smooth muscle area of the prostate tissue sample were identified, and then terahertz transmission spectral detection was performed on the 3 areas. Results There were correlations in the shape and size of the tumor areas identified by reflection imaging recognition and H-E staining (P<0.001). Significant differences were found in the absorption coefficient and refractive index measured by transmission spectra in the 3 areas (P<0.001). The absorption coefficient of terahertz spectrum was correlated with the percentage of nucleus (P<0.001). Moreover, there were differences in the absorption coefficient among the 5 groups of different tumor grades and groupings (P<0.001). Conclusion Terahertz imaging can clearly identify the contour of paraffin-embedded prostate tumor. Terahertz spectroscopy can not only distinguish smooth muscle, tumor and normal prostate tissue, but also identify prostate cancer of different grades and groupings. The optical reaction of tumor paraffin tissue to terahertz is related to the percentage of nucleus.

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备注/Memo

备注/Memo:
 【收稿日期】2019-04-07
【基金项目】国家自然科学基金（81760138）；海南省国际科技合作项目（GJXM201108）；海南省社会发展科技专项（ZDYF2017084）
【作者简介】张君席，硕士研究生，从事前列腺癌诊断的相关研究，E-mail: 1432678851@qq.com
【通信作者】刘振湘，教授，主任医师，从事前列腺癌诊断与治疗的相关研究，E-mail: liuzhenxianghk@163.com
更新日期/Last Update: 2019-05-23