[1]李煜瑶,李静,焦青,等. 2型糖尿病患者功能磁共振成像的局部脑区活动时空四维一致性[J].中国医学物理学杂志,2019,36(10):1162-1167.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.009]
　LI Yuyao,LI Jing,JIAO Qing,et al. Four-dimensional (spatio-temporal) consistency of local neural activity in type 2 diabetes patient on fMRI[J].Chinese Journal of Medical Physics,2019,36(10):1162-1167.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.009]
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 2型糖尿病患者功能磁共振成像的局部脑区活动时空四维一致性()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第10期
页码:
1162-1167
栏目:
医学影像物理
出版日期:
2019-10-29

文章信息/Info

Title:
 Four-dimensional (spatio-temporal) consistency of local neural activity in type 2 diabetes patient on fMRI
文章编号:
1005-202X（2019）10-1162-06
作者:
 李煜瑶1; 李静1; 焦青1; 薛雅卓2; 刘新凤3; 曹卫芳1; 郭永新1; 崔栋1; 刘明3
 1.山东第一医科大学（山东省医学科学院）放射学院， 山东 泰安 271016； 2.山东第一医科大学（山东省医学科学院）护理学院， 山东 泰安 271016； 3.山东省泰山医院内分泌科， 山东 泰安 271000
Author(s):
 LI Yuyao1;  LI Jing1;  JIAO Qing1;  XUE Yazhuo2;  LIU Xinfeng3;  CAO Weifang1;  GUO Yongxin1;  CUI Dong1;  LIU Ming3
 1. School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an 271016, China; 2. School of Nursing, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an 271016, China; 3. Department of Endocrinology, Shandong Provincial Taishan Hospital, Tai’an 271000, China
关键词:
 ; 2型糖尿病; 功能磁共振成像; 时空四维一致性; 血糖
Keywords:
 ; Keywords: type 2 diabetes;  functional magnetic resonance imaging;  four-dimensional (spatio-temporal) consistency;  plasma glucose
分类号:
R318；R814.42
DOI:
DOI:10.3969/j.issn.1005-202X.2019.10.009
文献标志码:
A
摘要:
 目的：利用功能磁共振成像（fMRI）及临床资料研究2型糖尿病（T2D）患者脑功能及血糖指标改变状况。方法：采集T2D患者（34例）及健康被试（37例）的fMRI信号，计算局部脑区神经活动时空四维一致性指标（FOCA），采集被试者临床实验室检查信息，并分析二者的相关性。结果：与健康对照组相比，T2D患者的FOCA值在左侧颞中回、右侧颞上回显著降低，在右侧小脑显著增加。左侧颞中回的FOCA值与空腹血糖指标、餐后血糖指标呈现显著的负相关。结论：T2D患者会出现右侧小脑、右侧颞上回、左侧颞中回等脑区自发神经活动的紊乱，且左侧颞中回的活动异常与T2D患者空腹及餐后2 h血糖水平等指标具有相关性。
Abstract:
 Abstract: Objective To investigate the abnormities in the brain function and plasma glucose level of type 2 diabetes (T2D) patients by functional magnetic resonance imaging (fMRI) and clinical data. Methods The fMRI signals of 34 T2D patients and 37 healthy controls were collected. The four-dimensional (spatio-temporal) consistency (FOCA) of local neural activities was calculated. The information of clinical laboratory examination of subjects was also collected, and the correlations between FOCA and clinical information were analyzed. Results Compared with that of healthy controls, the FOCA of T2D patients was significantly decreased in left middle temporal gyrus and right superior temporal gyrus, while increased in right cerebellum. The FOCA of left middle temporal gyrus was negatively correlated to fasting plasma glucose and postprandial blood glucose. Conclusion T2D patients have abnormal spontaneous neural activities in certain brain areas which includes right cerebellum, right superior temporal gyrus and left middle temporal gyrus, and the abnormal activity of left middle temporal gyrus is related to fasting blood glucose and two-hour postprandial plasma glucose in T2D patients.

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备注/Memo

备注/Memo:
 【收稿日期】2019-05-15
【基金项目】国家自然科学基金（81371531)；山东省医药卫生科技发展计划（2016WS0603）；山东省高校科技计划（J18KA262）；泰山医学院高层次课题培育计划（2017GCC11）
【作者简介】李煜瑶，研究方向：生物医学工程，E-mail: 2562389754@qq.com；李静，研究方向：生物医学工程，E-mail: 1282046287@qq.com
【通信作者】焦青，博士，教授，研究方向：磁共振成像技术、生物医学信号处理，E-mail: bingbao17@163.com
更新日期/Last Update: 2019-10-30