前节光学相干断层扫描在病毒感染性角膜炎诊治中的临床应用-《中国医学物理学杂志》

文章信息/Info

Title:: Clinical application of anterior segment optical coherence tomography in the diagnosis and treatment of virus infectious keratitis

Author(s):: SHAN Baiyang; ZHAO Haiyan; Department of Ophthalmology, Liaoyang Central Hospital, Liaoyang 111000, China

Keywords:: Keywords: anterior segment optical coherence tomography; herpes simplex virus; infectious keratitis; confocal microscope

摘要:: 目的：使用前节光学相干断层扫描（AS-OCT）研究早期体内单疱病毒感染性角膜炎治疗前后变化，为临床合理诊治提供依据。方法：3名角膜炎患者参与此项试验，采用共聚焦显微镜（CM）和AS-OCT观察3名患者不同药物治疗前后角膜变化。结果：通过AS-OCT显示的角膜强反光条带，成功获得所有患者的高分辨率疑似单疱病毒性角膜炎症状图片。强反光带的深度和宽度各不相同。一些条带从基质深层外围弯曲到前基质，另一些条带位于基质的不同深度，并且与角膜层相对平行。相比CM，AS-OCT更适用于角膜基质混浊形态宽度和深度的测量。结论：AS-OCT为早期单疱病毒性角膜炎的诊治提供了一种较为有效的辅助方法。

Abstract:: Abstract: Objective To investigate in vivo corneal changes before and after treatment in early-stage herpes simplex keratitis (HSK) using anterior segment optical coherence tomography (AS-OCT) so as to provide a reasonable basis for clinical diagnosis and treatment. Methods Three patients with keratitis were enrolled in the study. Confocal microscope and AS-OCT were used to observe corneal changes of 3 patients before and after being treated with certain medications. Results Based on the highly reflective bands in the corneal stroma displayed by AS-OCT, the high-resolution images of suspected HSK in all patients were successfully obtained. The depths and widths of the highly reflective bands varied from case to case. Some bands ran obliquely from the deep peripheral stroma toward the anterior stroma, and some were located at different depths and ran relatively parallel to the corneal layers. Compared with confocal microscope, AS-OCT was more suitable for the width and depth measurements of corneal stromal opacity. Conclusion AS-OCT provides a useful auxiliary method for the early diagnosis and treatment of HSK.