人工腰椎间盘置换术治疗退变性腰椎间盘病的应用现状-《中国医学物理学杂志》

文章信息/Info

Title:: Application status of artificial lumbar disc replacement for lumbar degenerative disc disease

作者:: 杨风光1; 2; 3; 任恩惠1; 2; 3; 杨亮1; 2; 3; 王永刚1; 2; 3; 汪静1; 2; 3; 康学文1; 2; 1. 兰州大学第二医院骨科，甘肃兰州730000；2. 甘肃省骨与关节疾病重点实验室，甘肃兰州730000；3. 脊柱疾患疼痛机制研究及治疗甘肃省国际科技合作基地，甘肃兰州730000

Author(s):: YANG Fengguang1; 2; 3; REN Enhui1; 2; 3; YANG Liang1; 2; 3; WANG Yonggang1; 2; 3; WANG Jing1; 2; 3; KANG Xuewen1; 2; 3; 1. Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730000, China; 2. Key Laboratory of Osteoarthritis of Gansu Province, Lanzhou 730000, China; 3. International Scientific and Technological Cooperation Base of Gansu Province for the Research on Pain Mechanism of Spinal Disorders, Lanzhou 730000, China

Keywords:: Keywords: lumbar degenerative disc disease; artificial lumbar disc replacement; biomechanical characteristic; review

摘要:: 【摘要】人工腰椎间盘置换术（ALDR）是利用人工假体替换病变椎间盘，恢复椎间隙高度的同时保持脊柱的稳定性和一定的活动范围，降低邻椎病的发生率，是治疗腰椎间盘退变性疾病（LDDD）的新方法，本研究就ALDR治疗LDDD的临床应用现状作一综述。Charité、ProDisc以及Activ-L是临床常用的人工椎间盘，但由于疗效不明显，Charité 系列人工椎间盘已于2012年逐渐从市场撤出；目前临床常用的ProDisc系列人工腰椎间盘有ProDisc Ⅱ 和ProDisc-L。ALDR可有效保留置换节段的活动度，降低邻椎病的发生率，对LDDD有较好的中短期疗效，但是假体下沉、移位、磨损、异位骨化及晚期置换节段融合等并发症的发生不容忽视。ALDR对LDDD的长期临床疗效以及潜在并发症仍需要长期的、大样本的随访研究。

Abstract:: Abstract: Artificial lumbar disc replacement (ALDR) is an innovative treatment of lumbar disc degeneration disease (LDDD) by replacing the intervertebral disc with artificial prosthesis, restoring the height of the intervertebral space while maintaining the stability of the spine and a certain range of motion, thereby reducing the incidence of adjacent segment disease. Herein the current clinical applications of artificial lumbar disc replacement in the treatment of LDDD are reviewed. Charité, ProDisc and Activ-L are commonly used artificial intervertebral discs in clinic. Due to the lack of obvious curative effect, the artificial intervertebral discs of Charité series have been gradually withdrawn from the market in 2012. For the artificial intervertebral discs of ProDisc series, ProDisc II and ProDisc-L are commonly used in clinic. ALDR which can effectively retain the range of motion of the replacement segment and reduce the incidence of adjacent segment disease has good short- and medium-term therapeutic effects on LDDD. However, the complications such as the subsidence, displacement and wear of prosthesis, heterotopic ossification and late replacement segment fusion can’t be ignored. Long-term clinical efficacy and potential complications of ALDR for LDDD still require long-term, large-sample follow-up studies.