[1]韩鹏炳,李瑾,冀雪娟,等. 加味冰硼散联合云南白药对放射性口腔黏膜炎患者的疗效[J].中国医学物理学杂志,2019,36(4):398-401.[doi:DOI:10.3969/j.issn.1005-202X.2019.04.006]
　HAN Pengbing,LI Jin,JI Xuejuan,et al. Therapeutic effects of modified Bingpeng powder combined with Yunnan Baiyao on radiation-induced oral mucositis[J].Chinese Journal of Medical Physics,2019,36(4):398-401.[doi:DOI:10.3969/j.issn.1005-202X.2019.04.006]
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 加味冰硼散联合云南白药对放射性口腔黏膜炎患者的疗效()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第4期
页码:
398-401
栏目:
医学放射物理
出版日期:
2019-04-25

文章信息/Info

Title:
 Therapeutic effects of modified Bingpeng powder combined with Yunnan Baiyao on radiation-induced oral mucositis
文章编号:
1005-202X（2019）04-0398-04
作者:
 韩鹏炳1; 李瑾1; 冀雪娟2; 高力英1; 张桂琼1
 1.甘肃省肿瘤医院放疗科， 甘肃 兰州 730050； 2.兰州市西固区中医院康复科， 甘肃 兰州 730050
Author(s):
 HAN Pengbing1;  LI Jin1;  JI Xuejuan2;  GAO Liying1;  ZHANG Guiqiong1
 1. Department of Radiology, Gansu Provincial Cancer Hospital, Lanzhou 730050, China; 2. Department of Rehabilitation，Xigu District of Lanzhou City Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
 ; 放射性口腔黏膜炎; 加味冰硼散; 云南白药
Keywords:
 ; Keywords: radiation-induced oral mucositis;  modified Bingpeng powder;  Yunnan Baiyao
分类号:
R739.6
DOI:
DOI:10.3969/j.issn.1005-202X.2019.04.006
文献标志码:
A
摘要:
 目的：探讨加味冰硼散联合云南白药对放射性口腔黏膜炎患者的疗效。方法：随机选取甘肃省肿瘤医院于2016年4月至2018年4月期间收治的放射性口腔黏膜炎患者82例，随机分为观察组（41例）与对照组（41例）。两组患者均于放疗前进行口腔预处理，包括3%双氧水冲洗和全口超声波牙周洁治等。对照组给予云南白药散剂含漱，观察组在对照组基础上结合加味冰硼散进行治疗。两组均以出现炎症开始进行治疗至放疗结束后1周。结果：观察组口腔黏膜分级0~I级的例数明显多于对照组，有统计学差异（P<0.05）。观察组口咽疼痛分级0~1级的例数明显多于对照组，有统计学差异（P<0.05）。两组治疗后白介素-2（IL-2）、白介素-4（IL-4）和肿瘤坏死因子-α（TNF-α）水平较治疗前降低，而白介素-10（IL-10）水平较治疗前升高；观察组治疗后IL-2、IL-4和TNF-α水平低于对照组，而IL-10水平高于对照组，有统计学差异（P<0.05）。结论：加味冰硼散联合云南白药对放射性口腔黏膜炎患者的治疗效果显著，且可减轻炎症反应。
Abstract:
 Abstract: Objective To investigate the therapeutic effects of the combined use of modified Bingpeng powder and Yunnan Baiyao on radiation-induced oral mucositis. Methods A total of 82 patients with radiation-induced oral mucositis treated in Gansu Provincial Cancer Hospital from April 2016 to April 2018 were randomly selected and then divided into observation group (41 cases) and control group (41 cases). Two groups of patients received oral pretreatment before radiotherapy, including 3% hydrogen peroxide irrigation, full-mouth ultrasonic teeth cleaning and so on. Control group was given Yunnan Baiyao powder gargle, while observation group was treated with Yunnan Baiyao powder gargle and modified Bingpeng powder. The treatments in both groups began from inflammation to 1 week after the end of radiotherapy. Results The number of patients with oral mucosa of level 0-I in observation group was significantly more than that in control group (P<0.05). Moreover, the number of patients with oropharyngeal pain of grade 0-1 in observation group was significantly more than that in control group (P<0.05). After treatment, the levels of IL-2, IL-4 and TNF-α in the two groups were lower, while the level of IL-10 in the two groups was higher than before. After treatment, the levels of IL-2, IL-4 and TNF-α in observation group were lower than those in control group, and the IL-10 level was higher than that of control group (P<0.05). Conclusion Modified Bingpeng powder combined with Yunnan Baiyao not only has remarkable therapeutic effects on radiation-induced oral mucositis, but also reduce inflammation.

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备注/Memo

备注/Memo:
 【收稿日期】2018-11-12
【基金项目】甘肃省中医药管理局科研课题（GZK-2017-40）
【作者简介】韩鹏炳，主治医师，研究方向：头颈部及脑部恶性肿瘤的放射治疗，E-mail: hpbflzy@163.com
【通信作者】高力英，主任医师，研究方向：头颈部及脑部恶性肿瘤的放射治疗，E-mail: lygaolanzhou@163.com
更新日期/Last Update: 2019-04-23