[1]叶淑敏,滕建建,石锦平,等. MLC叶片系统误差对鼻咽癌VMAT和IMRT计划剂量影响的比较[J].中国医学物理学杂志,2019,36(10):1139-1144.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.005]
　YE Shumin,TENG Jianjian,SHI Jinping,et al. Comparison of dosimetric impacts of MLC systematic errors on VMAT and IMRT plans for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2019,36(10):1139-1144.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.005]
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 MLC叶片系统误差对鼻咽癌VMAT和IMRT计划剂量影响的比较()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第10期
页码:
1139-1144
栏目:
医学放射物理
出版日期:
2019-10-29

文章信息/Info

Title:
 Comparison of dosimetric impacts of MLC systematic errors on VMAT and IMRT plans for nasopharyngeal carcinoma
文章编号:
1005-202X（2019）10-1139-06
作者:
 叶淑敏; 滕建建; 石锦平; 张利文; 刘致滨
 佛山市第一人民医院/中山大学附属佛山医院肿瘤中心放疗科， 广东 佛山 528000
Author(s):
 YE Shumin;  TENG Jianjian;  SHI Jinping;  ZHANG Liwen;  LIU Zhibin
 Department of Radiation Oncology, Cancer Center, First People’s Hospital of Foshan/Affiliated Foshan Hospital of Sun Yat-sen University, Foshan 528000, China
关键词:
 ; 鼻咽癌; 多叶准直器; 系统误差; 调强放疗; 容积调强; 剂量学
Keywords:
 ; Keywords: nasopharyngeal carcinoma;  multi-leaf collimator;  systematic error;  intensity-modulated radiotherapy;  volumetric modulated arc therapy;  dosimetry
分类号:
R815.6
DOI:
DOI:10.3969/j.issn.1005-202X.2019.10.005
文献标志码:
A
摘要:
 【摘要】目的：研究多叶准直器（MLC）叶片系统误差对鼻咽癌容积调强（VMAT）计划和普通调强（IMRT）计划剂量学影响的差异。方法：随机选取20例鼻咽癌患者，分别设计VMAT计划和IMRT计划。通过MATLAB 2009a只修改计划文件中MLC运动叶片的位置，人为引入0.2、0.5、1.0 mm的系统误差，导入治疗计划系统中重新进行剂量计算。对两种调强技术，比较靶区和危及器官生物学剂量（gEUD）受叶片位置误差影响的差异，并研究gEUD差值与叶片误差之间的关系。结果：靶区和危及器官两种计划gEUD的变化差异具有统计学意义（P<0.01）。PGTV、PTVnd、PTV1、PTV2、脑干、脊髓、左侧腮腺、右侧腮腺等gEUD的变化与叶片误差成线性关系，VMAT计划分别变化为3.6、3.8、4.0、3.0、5.6、5.6、6.8、6.8 %/mm（P<0.001）；IMRT计划分别变化为10.7、10.5、11.2、10.7、16.6、15.0、14.6、14.4 %/mm（P<0.001）。结论：MLC叶片系统误差对VMAT计划剂量的影响比IMRT计划小。为保证PGTV的gEUD变化控制在2%以内，VMAT和IMRT叶片系统误差应分别小于0.6和0.2 mm。
Abstract:
 Abstract: Objective To study the differences in the dosimetric impacts of multi-leaf collimator (MLC) systematic errors on volumetric modulated arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) plans for nasopharyngeal carcinoma. Methods Twenty patients with nasopharyngeal carcinoma were randomly enrolled in the study. Two different plans, namely VMAT and IMRT, were designed for each patient. The systematic errors of 0.2, 0.5, 1.0 mm were manually generated by only changing the positions of MLC leaves in the treatment plan file via MATLAB 2009a. The dose was recomputed after the modified plan file was inputted to treatment planning system. The impacts of MLC systematic errors on generalized equivalent uniform dose (gEUD) of planning target volume (PTV) and organ-at-risk between two plans were compared, and the relationship between gEUD difference and MLC systematic errors was analyzed. Results There were statistical differences in the gEUD variations of PTV and organs-at-risk between two plans (P<0.001). The gEUD variations of PGTV, PTVnd, PTV1, PTV2, brainstem, spinal cord, left parotid gland and right parotid gland varied linearly with MLC systematic errors. The corresponding gEUD variations due to MLC systematic errors in VMAT plan were 3.6, 3.8, 4.0, 3.0, 5.6, 5.6, 6.8 and 6.8 %/mm, respectively (P<0.001), which were less than 10.7, 10.5, 11.2, 10.7, 16.6, 15.0, 14.6 and 14.4 %/mm in IMRT plan (P<0.001). Conclusion MLC systematic error has a greater dosimetric impact on IMRT plan than VMAT plan. The MLC system errors in VMAT and IMRT should be less than 0.6 and 0.2 mm, respectively, so as to ensure that the gEUD variation of PGTV is controlled within 2%.

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备注/Memo

备注/Memo:
 【收稿日期】2019-05-12
【基金项目】国家科技部课题（2017YFC0113205）
【作者简介】叶淑敏，主管技师，研究方向：肿瘤精准放射治疗，E-mail: fsysmin@163.com
【通信作者】石锦平，主任技师，研究方向：肿瘤精准放射治疗，E-mail: rath55@126.com
更新日期/Last Update: 2019-10-29