[1]贺瑶瑶,荆亮,黄晓铧,等.基于个性化组织等效体模的肺癌三维适形放疗计划算法比较[J].中国医学物理学杂志,2019,36(7):755-759.[doi:DOI:10.3969/j.issn.1005-202X.2019.07.003]
　HE Yaoyao,,et al.Comparison of three-dimensional conformal radiotherapy planning algorithms for lung cancerbased on personalized tissue-equivalent phantom[J].Chinese Journal of Medical Physics,2019,36(7):755-759.[doi:DOI:10.3969/j.issn.1005-202X.2019.07.003]
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基于个性化组织等效体模的肺癌三维适形放疗计划算法比较()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第7期
页码:
755-759
栏目:
医学放射物理
出版日期:
2019-07-25

文章信息/Info

Title:
Comparison of three-dimensional conformal radiotherapy planning algorithms for lung cancer based on personalized tissue-equivalent phantom
文章编号:
1005-202X（2019）07-0755-05
作者:
贺瑶瑶1; 2; 3; 荆亮4; 黄晓铧1; 2; 3; 鞠楠1; 2; 3; 张福全1; 2; 3; 潘珏宇1; 2; 3; 邱建峰1; 2; 3; 邢晓颖1; 2; 3; 刘雯倩1; 2; 3; 侯立霞3
1. 山东第一医科大学（山东省医学科学院）医学工程技术研究中心，山东泰安271016；2.Imaging-X 联合实验室，山东泰安 271016；3. 山东第一医科大学（山东省医学科学院）放射学院，山东泰安271016；4.泰安市肿瘤医院放疗科，山东泰安271000
Author(s):
HE Yaoyao1;  2;  3;  JING Liang4;  HUANG Xiaohua1;  2;  3;  JU Nan1;  2;  3;  ZHANG Fuquan1;  2;  3;  PAN Jueyu1; 2; 3;  QIU Jianfeng1;  2;  3;  XING Xiaoying1;  2;  3;  LIUWenqian1;  2;  3;  HOU Lixia3
1. Research Center of Medical Engineering Technology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an 271016, China; 2. Imaging-X Joint Laboratory, Tai’an 271016, China; 3. School of Radiology, Shandong First Medical University, Tai’an 271016, China; 4. Department of Radiotherapy, Tai’an Cancer Hospital, Tai’an 271000, China
关键词:
体模; 筒串卷积算法; 光子笔形束卷积算法; 蒙卡算法; 三维适形放疗
Keywords:
Keywords: phantom;  collapse cone convolution algorithm;  pencil beam convolution algorithm;  Monte Carlo algorithm;  threedimensional conformal radiotherapy
分类号:
R814.2；R318
DOI:
DOI:10.3969/j.issn.1005-202X.2019.07.003
文献标志码:
A
摘要:
目的：通过比较体模测量点算法计算值与实际测量值的辐射剂量差异，比较放射治疗计划系统（TPS）中蒙卡算法 （MC）、光子笔形束卷积算法（PBC）和筒串卷积算法（CCC）在计算肺癌三维立体定向放疗计划的差异。方法：将个性化组 织等效胸部体模的CT图像传输至TPS系统，勾勒靶区，并制定合适的投照计划。将肿瘤组织、肺内正常组织与脊髓3个 测量点单独插入电离室，并用相对应的等效材料的仿真块填补剩余2个预留测量点位置，再进行CT扫描。通过影像融合 匹配图层、统一靶区，根据投照计划进行实际投照，并分别用3种算法进行辐射剂量的计算（计算值）。结果：个性化仿真 胸部体模的脂肪组织、肌肉组织、骨和肿瘤的CT值分别为（-100±30）、（40±20）、（210±90）和（33±16）HU，与患者的CT值 范围相近，接近组织辐射等效。CCC、MC和PBC算法对肺部正常组织的计算误差分别为2.51%、-2.51%、1.02%，对肿瘤 组织剂量计算误差分别为0.18%、0.66%、0.42%，对脊髓剂量的计算误差分别为7.32%、9.76%和-53.66%。结论：通过组织 等效体模比较MC、PBC、CCC算法在三维适形放疗计划的剂量计算。MC算法与CCC算法计算值均高估肿瘤组织、肺部 正常组织和脊髓的剂量。MC算法计算肿瘤组织比CCC算法略有优势，但计算肺部正常组织与脊髓的剂量明显差于CCC 算法。PBC算法在计算脊髓组织剂量上误差较大，可能是因为PBC算法在非均匀组织计算中未考虑计算点周围散射线 的影响，故不推荐使用PBC算法。
Abstract:
Abstract: Objective To compare the difference of radiation dose between the calculated value and the measured value, and then compare the differences among Monte Carlo (MC) algorithm, pencil beam convolution (PBC) algorithm and collapse cone convolution (CCC) algorithm of Treatment Planning System (TPS) in three-dimensional stereotactic radiotherapy for lung cancer. Methods The CT images of anthropomorphic thorax phantom were imported to TPS. The target areas were delineated and a suitable projection plan was established. Three measurement points of tumor tissues, normal lung tissues and spinal cord were inserted into ionization chamber, separately. After the corresponding equivalent materials were used to fill the remaining 2 measurement points, CT scan was performed. The projection plan was implemented based on the image fusion for registration and the unification of target areas, and all 3 algorithms were used for dose calculation. Results The CT numbers of adipose tissues, muscle tissues, bone and tumor of anthropomorphic thorax phantom were (-100±30), (40±20), (210±90) and (33±16) HU, respectively, which were similar to the CT numbers of patients. The errors of CCC, MC and PBC algorithms in the calculation of the dose of normal lung tissues were 2.51%, -2.51% and 1.02%, respectively; the errors in the calculation of tumor tissue dose were 0.18%, 0.66% and 0.42%, respectively; and the errors in the calculation of spinal cord dose were 7.32%, 9.76% and -53.66%, respectively. Conclusion The dose calculation of MC, PBC and CCC algorithms in three-dimensional conformal radiotherapy was compared with the use of tissue-equivalent phantom. Both MC and CCC algorithms overestimate the doses of tumor tissues, normal lung tissues and spinal cord. MC algorithm is slightly better than CCC algorithm in the calculation of tumor tissue dose, but is inferior to CCC algorithm in the calculation of the doses of normal lung tissue and spinal cord. PBC algorithm is not recommended, because it does not consider the effect of scattering lines around the calculating points on the calculation of inhomogeneous tissue dose, which results in a large error in the calculation of spinal cord tissue dose.

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备注/Memo

备注/Memo:
【收稿日期】2019-03-08 【基金项目】国家重点研发计划（2016YFC0103400）；山东省重点研究发展计划（2017GSF218075） 【作者简介】贺瑶瑶，在读研究生，研究方向：医学物理与医学成像，E-mail: heyaoyao628@163.com；荆亮，本科，物理师，研究方向：放疗计划设计及 加速器质控，E-mail: brucejing@126.com 【通信作者】侯立霞，副教授，研究方向：辐射防护，E-mail: yyhe628@163.com
更新日期/Last Update: 2019-07-24