[1]田伟,戴建荣. 子野小数机器跳数取整对鼻咽癌静态调强放射治疗计划剂量学的影响[J].中国医学物理学杂志,2018,35(10):1128-1133.[doi:DOI:10.3969/j.issn.1005-202X.2018.10.003]
　TIAN Wei,DAI Jianrong. Dosimetric effects of rounding subfield monitor units up for step-and-shoot IMRT plan of nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2018,35(10):1128-1133.[doi:DOI:10.3969/j.issn.1005-202X.2018.10.003]
点击复制

 子野小数机器跳数取整对鼻咽癌静态调强放射治疗计划剂量学的影响()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第10期
页码:
1128-1133
栏目:
医学放射物理
出版日期:
2018-10-25

文章信息/Info

Title:
 Dosimetric effects of rounding subfield monitor units up for step-and-shoot IMRT plan of nasopharyngeal carcinoma
文章编号:
1005-202X（2018）10-1128-06
作者:
 田伟; 戴建荣
 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院， 北京 100021
Author(s):
 TIAN Wei;  DAI Jianrong
 National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
关键词:
 ; 鼻咽癌; 计划系统; 调强放射治疗; 小数跳数; 剂量学
Keywords:
 ; Keywords: nasopharyngeal carcinoma;  treatment planning system;  intensity-modulated radiotherapy;  decimal monitor unit;  dosimetry
分类号:
R815
DOI:
DOI:10.3969/j.issn.1005-202X.2018.10.003
文献标志码:
A
摘要:
 目的：探讨Prowess5.1计划系统在鼻咽癌静态调强放疗（IMRT）计划设计时子野小数机器跳数（MU）的四舍五入取整对计划剂量学的影响。 方法：选择33例病理诊断明确的鼻咽癌患者的IMRT计划纳入研究，分为两组计划：计划系统优化完成的原始计划组为Porig；对原始计划组的子野小数机器跳数四舍五入取整，做最终剂量计算后生成新计划组Pnew。两组计划所有子野形状未改变，比较两组计划的MU变化及剂量学差异。 结果：两组计划所有靶区的CI和HI相近，差异均无统计学意义；Pnew组靶区覆盖率、PGTVnd的D98、D95、D2、Dmean及PTV2的D98、D95，Pnew组均低于Porig组（P<0.05），PGTVnd、PTVnx和PTV1的V100%分别降低了1.807%、0.655%和1.258%；危及器官仅左颞叶的Dmean差异具有统计学意义（P<0.05）；对于P1计划，单次Pnew比Porig跳数增加了1.600，差异具有统计学意义（519.758±46.410 vs 518.158±46.693, P<0.05)。 结论：Prowess5.1计划系统在制定鼻咽癌静态调强IMRT计划时，子野小数MU的微小变化会引起剂量学的变化，临床实践中应引起重视。
Abstract:
 Abstract: Objective To investigate the dosimetric effects of rounding subfield monitor units (MU) up to their nearest integers in step-and-shoot intensity-modulated radiotherapy (IMRT) plans for nasopharyngeal carcinoma (NPC) which was designed by Prowess5.1 planning system. Methods The IMRT plans for 33 NPC patients with definite pathological diagnosis were enrolled into this study. These IMRT plans were divided into two groups, namely Porig and Pnew. Porig was composed of all the original plans which had been optimized completely by the treatment planning system itself. Pnew was a new group of which all the subfield monitor unit were rounded up to their nearest integers based on Porig, and the shapes of segments in Pnew were all the same as those in Porig. The dosimetric characteristics and MU differences were recorded and compared between Porig and Pnew. Results The conformity index and homogeneity index of target areas in two groups were similar, without statistical significance. The target coverage, the D98, D95, D2, Dmean of PGTVnd, and the D98, D95 of PTV2 in Pnew were lower than those in Porig (P<0.05). The V100% of PGTVnd, PTVnx and PTV1 were decreased by 1.807%, 0.655% and 1.258%, respectively. For organs-at-risk, only the Dmean of left temporal lobe showed statistical differences between two groups (P<0.05). For P1 plans, the MU per fraction in Pnew was increased by 1.600 MU as compared with Porig (519.758±46.410 vs 518.158±46.693, P<0.05). Conclusion When Prowess5.1 planning system is used to design step-and-shoot IMRT plan for NPC, the tiny changes of subfield monitor units will cause dosimetric differences. Hence the calculation of monitor units should be paid attention to in clinical practice.

相似文献/References:

[1]陈广涛,汪 淇,刘亚强,等.TrueBeam加速器射野准直器跟随功能在鼻咽癌固定野调强放疗和容积旋转调强放疗中的应用[J].中国医学物理学杂志,2014,31(03):4865.[doi:10.3969/j.issn.1005-202X.2014.03.005]
[2]潘宇辉,陈榕钦,柏朋刚,等.鼻咽癌调强放射治疗前后腮腺体积及空间几何位置变化研究[J].中国医学物理学杂志,2014,31(05):5120.[doi:10.3969/j.issn.1005-202X.2014.05.005]
[3]张俊俊,邱小平,李奇欣,等.ArcCheck系统在鼻咽癌容积旋转调强剂量验证中的应用[J].中国医学物理学杂志,2014,31(05):5136.[doi:10.3969/j.issn.1005-202X.2014.05.009]
[4]桑 勇,陈维军,狄小云,等.多叶光栅叶片宽度对鼻咽癌剂量学的影响[J].中国医学物理学杂志,2014,31(06):5240.[doi:10.3969/j.issn.1005-202X.2014.06.004]
[5]黄利生,庄婷婷,伍方财,等.鼻咽癌调强放疗Ib区剂量分析[J].中国医学物理学杂志,2014,31(06):5265.[doi:10.3969/j.issn.1005-202X.2014.06.010]
[6]易金玲,金献测,周永强,等.鼻咽癌IMRT与VMAT治疗的计划与剂量验证比较研究[J].中国医学物理学杂志,2013,30(01):3859.[doi:10.3969/j.issn.1005-202X.2013.01.006]
[7]金献测,易金玲,周永强,等.鼻咽癌同步加量调强放射治疗新的计划质量评估指标研究[J].中国医学物理学杂志,2013,30(02):3978.[doi:10.3969/j.issn.1005-202X.2013.02.004]
[8]蒋晓芹,段宝风,艾平,等.基于图谱库的自动轮廓勾画软件(ABAS)在鼻咽癌调强放疗中的应用[J].中国医学物理学杂志,2013,30(02):3997.[doi:10.3969/j.issn.1005-202X.2013.02.008]
[9]张达光,蒋胜鹏,李智华,等.鼻咽癌调强放疗中解剖结构改变及剂量分布变化的研究[J].中国医学物理学杂志,2013,30(04):4239.[doi:10.3969/j.issn.1005-202X.2013.04.006]
[10]杨海燕,王军良,周振山,等.AAA算法和PBC算法在鼻咽癌调强放疗中剂量分布的比较[J].中国医学物理学杂志,2013,30(04):4245.[doi:10.3969/j.issn.1005-202X.2013.04.008]
[11]张晓辉,王淑侠,徐卫平,等. PET/CT增强在鼻咽癌头颈部淋巴结转移的应用价值[J].中国医学物理学杂志,2016,33(9):939.[doi:10.3969/j.issn.1005-202X.2016.09.014]
　[J].Chinese Journal of Medical Physics,2016,33(10):939.[doi:10.3969/j.issn.1005-202X.2016.09.014]
[12]蒋璐,邱小平,单国平,等. 鼻咽癌放疗中摆位误差及解剖结构变化对剂量学的影响[J].中国医学物理学杂志,2017,34(4):348.[doi:DOI:10.3969/j.issn.1005-202X.2017.04.006]
[13]胡邦,唐承佩,刘小芳,等. 基于等效均匀剂量的目标函数对鼻咽癌调强放疗中颞叶的保护[J].中国医学物理学杂志,2017,34(5):472.[doi:DOI:10.3969/j.issn.1005-202X.2017.05.008]
[14]王占宇,曾自力,谭军文. 基于电子射野影像系统的鼻咽癌调强放疗摆位误差纠正及其应用[J].中国医学物理学杂志,2017,34(9):887.[doi:DOI:10.3969/j.issn.1005-202X.2017.09.006]
　[J].Chinese Journal of Medical Physics,2017,34(10):887.[doi:DOI:10.3969/j.issn.1005-202X.2017.09.006]
[15]苏欢繁,全红,梁志文,等.鼻咽癌放疗中3种调强技术对摆位误差的敏感性[J].中国医学物理学杂志,2017,34(11):1102.[doi:DOI:10.3969/j.issn.1005-202X.2017.11.005]
　SU Huanfan,QUAN Hong,LIANG Zhiwen,et al. Sensitivity of 3 kinds of intensity-modulated radiotherapy techniques to setup errors in radiotherapy for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2017,34(10):1102.[doi:DOI:10.3969/j.issn.1005-202X.2017.11.005]
[16]刘礼东,杨振,邱小平,等. 利用Delta4对放疗计划进行剂量体积直方图评价的可行性研究[J].中国医学物理学杂志,2018,35(1):25.[doi:DOI:10.3969/j.issn.1005-202X.2018.01.006]
　LIU Lidong,YANG Zhen,QIU Xiaoping,et al. Feasibility of Delta4 for plan evaluation based on dose-volume histogram[J].Chinese Journal of Medical Physics,2018,35(10):25.[doi:DOI:10.3969/j.issn.1005-202X.2018.01.006]
[17]赵洪利,刘晖,钟亚华,等. TomoDirect技术在鼻咽癌放疗中的剂量学研究[J].中国医学物理学杂志,2018,35(2):166.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.009]
　ZHAO Hongli,LIU Hui,ZHONG Yahua,et al. Dosimetric study of TomoDirect technology in radiotherapy for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2018,35(10):166.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.009]
[18]刘国才,官文静,田娟秀,等. 集成自适应回归核的肿瘤生物靶区随机游走勾画方法[J].中国医学物理学杂志,2018,35(7):758.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.004]
　LIU Guocai,GUAN Wenjing,TIAN Juanxiu,et al. A random walk method with adaptive regression-kernel for delineation of biological target volumes of tumors[J].Chinese Journal of Medical Physics,2018,35(10):758.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.004]
[19]滕建建,石锦平,张利文,等. 鼻咽癌容积调强剂量验证与计划复杂性的相关性[J].中国医学物理学杂志,2018,35(7):781.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.008]
　TENG Jianjian,SHI Jinping,ZHANG Liwen,et al. Correlation between dose verification and plan complexity of volumetric modulated arc therapy for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2018,35(10):781.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.008]
[20]杨海松,聂晓历,刘利彬,等. 鼻咽癌螺旋断层调强放疗中优化MVCT扫描范围的可行性[J].中国医学物理学杂志,2018,35(8):874.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.002]
　YANG Haisong,NIE Xiaoli,LIU Libin,et al. Feasibility on optimizing MVCT scan range in tomotherapy of nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2018,35(10):874.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.002]

备注/Memo

备注/Memo:
 【收稿日期】2018-08-14
【作者简介】田伟，物理师，工程师，研究方向：医学物理，E-mail: 444835624@qq.com
【通信作者】戴建荣，博士，二级研究员，研究方向：治疗计划优化算法、图像引导放疗等，E-mail: dai_jianrong@163.com
更新日期/Last Update: 2018-10-22