[1]张娜,郭旭东,许堂成,等. 电子释药胶囊智能给药驱动装置的仿真与设计[J].中国医学物理学杂志,2019,36(3):334-339.[doi:DOI:10.3969/j.issn.1005-202X.2019.03.018]
　ZHANG Na,GUO Xudong,XU Tangcheng,et al. Simulation and design of an intelligent drug delivery driving device of electronic capsule[J].Chinese Journal of Medical Physics,2019,36(3):334-339.[doi:DOI:10.3969/j.issn.1005-202X.2019.03.018]
点击复制

 电子释药胶囊智能给药驱动装置的仿真与设计()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第3期
页码:
334-339
栏目:
医学信号处理与医学仪器
出版日期:
2019-03-25

文章信息/Info

Title:
 Simulation and design of an intelligent drug delivery driving device of electronic capsule
文章编号:
1005-202X（2019）03-0334-06
作者:
 张娜1; 郭旭东1; 许堂成1; 张慧河1; 王晶2
 1.上海理工大学医疗器械与食品学院， 上海 200093； 2.江苏爱朋医疗科技股份有限公司， 江苏 南通 226400
Author(s):
 ZHANG Na1;  GUO Xudong1;  XU Tangcheng1;  ZHANG Huihe1;  WANG Jing2
 1. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; 2. Jiangsu Apon Medical Technology Co., Ltd., Nantong 226400, China
关键词:
 ; 电子胶囊; 磁线圈-双永磁体驱动装置; 多次释药; 函数关系拟合; 驱动力智能调节
Keywords:
 ; Keywords: electronic capsule;  driving device based on electromagnetic coil-double permanent magnet;  multiple drug delivery;  function relationship fitting;  intelligent adjustment of driving force
分类号:
R318；TP273.5
DOI:
DOI:10.3969/j.issn.1005-202X.2019.03.018
文献标志码:
A
摘要:
 为了实现胃肠道电子释药胶囊的释药剂量、释药时间的智能控制，设计驱动力智能可调的电磁线圈-双永磁体驱动装置，以实现电子胶囊给药驱动力的准确控制。为建立给药驱动力F、电磁线圈行程d、激磁电流I的数学模型，实现驱动力的可控，设计给药驱动装置的原理样机，搭建给药驱动力测试平台。采用Polynomial理论建立给药驱动力数学模型，对比不同参数的驱动力模型对应的R2（R-square）、均方根误差，选用I、d的最高次幂分别为1次幂、5次幂构建的数学模型达到最优的拟合精度。根据拟合模型，由激磁电流调节模块实时改变电磁线圈的激磁电流，实现释药剂量、释药时间的可控。由实验验证可知：给药驱动力模型正确可行，为释药驱动力的智能可调提供理论基础。
Abstract:
 Abstract: An intelligently adjustable drug delivery driving device based on electromagnetic coil-double permanent magnet is designed to realize the intelligent control of release dosage and release time of electronic capsules for gastrointestinal diseases. A mathematical model based on drug delivery driving force F, electromagnetic coil stroke d, and exciting current I is established to achieve controllable driving force. Moreover, a prototype of the drug delivery driving device is designed, and a platform for the test of drug delivery driving force is set up. The mathematical model of drug delivery driving force was established using Polynomial theory. The R2 (R-square) and root mean square error of the driving force model with different parameters were compared. When the highest power of I and d were chosen to be 1 power and 5 power, respectively, the fitting accuracy of the mathematical model is the best. According to the fitting model, the real-time excitation current of the electromagnetic coil was adjusted by excitation current adjustment module, so as to achieve the controllable release dosage and release time. The experimental verification showed that the driving force model is correct and feasible, providing a theoretical basis for the intelligent adjustment of drug delivery driving force.

相似文献/References:

[1]王遥,霍万里,熊壮,等.TACE手术中不同站姿下铅眼镜和铅面罩对医生眼晶状体防护效果的蒙特卡洛模拟比较[J].中国医学物理学杂志,2016,33(6):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
　[J].Chinese Journal of Medical Physics,2016,33(3):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
[2]张新,谷晓芳,王培臣,等.轻离子束治疗设备注册检验关键技术问题[J].中国医学物理学杂志,2016,33(6):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
　[J].Chinese Journal of Medical Physics,2016,33(3):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
[3]江芬芬,王培,康盛伟,等. 热释光剂量片测量肺部肿瘤放疗剂量的方法[J].中国医学物理学杂志,2016,33(6):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
　[J].Chinese Journal of Medical Physics,2016,33(3):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
[4]刘洪源,彭威,杨锐,等. 锥形束CT离线校正肺癌摆位误差[J].中国医学物理学杂志,2016,33(6):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
　[J].Chinese Journal of Medical Physics,2016,33(3):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
[5]赵彪,潘香,杨毅,等. 右乳癌保乳术后瘤床同步X线和后程电子线补量调强放疗剂量学比较[J].中国医学物理学杂志,2016,33(6):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
　[J].Chinese Journal of Medical Physics,2016,33(3):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
[6]邓南,钱建庭,刁现芬,等. 基于宽带检测放疗X-光光声效应仿体实验[J].中国医学物理学杂志,2016,33(9):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
　[J].Chinese Journal of Medical Physics,2016,33(3):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
[7]张先稳,李军,张西志,等. 宫颈癌术后5野调强放疗4个变量组合的最佳治疗模式的剂量学[J].中国医学物理学杂志,2016,33(9):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
　[J].Chinese Journal of Medical Physics,2016,33(3):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
[8]胡健,李承军,徐利明,等. 床面倾斜对剂量验证通过率的影响[J].中国医学物理学杂志,2016,33(9):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
　[J].Chinese Journal of Medical Physics,2016,33(3):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
[9]陈亚正,肖明勇,孙春堂,等. 准直器角度对宫颈癌术后VMAT计划的影响[J].中国医学物理学杂志,2016,33(9):885.[doi:10.3969/j.issn.1005-202X.2016.09.004]
　[J].Chinese Journal of Medical Physics,2016,33(3):885.[doi:10.3969/j.issn.1005-202X.2016.09.004]
[10]李毅,唐丰文,张晓智. 基于四维CT和锥形束CT确定非小细胞肺癌放疗靶区外放边界[J].中国医学物理学杂志,2016,33(9):892.[doi:10.3969/j.issn.1005-202X.2016.09.005]
　[J].Chinese Journal of Medical Physics,2016,33(3):892.[doi:10.3969/j.issn.1005-202X.2016.09.005]

备注/Memo

备注/Memo:
 【收稿日期】2018-11-18
【基金项目】国家自然科学基金（61001164）；上海市自然科学基金（15ZR1428200）
【作者简介】张娜，硕士研究生，主要研究方向：精密工程与智能微系统，E-mail: 18817370919@163.com
更新日期/Last Update: 2019-03-26