[1]谢雨杉,汪艳芳,黄文华. 医学3D打印技术在视网膜修复的研究进展[J].中国医学物理学杂志,2019,36(2):234-238.[doi:DOI:10.3969/j.issn.1005-202X.2019.02.021]
　XIE Yushan,WANG Yanfang,HUANG Wenhua,et al. Research progress on 3D printing technology in retinal repair[J].Chinese Journal of Medical Physics,2019,36(2):234-238.[doi:DOI:10.3969/j.issn.1005-202X.2019.02.021]
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 医学3D打印技术在视网膜修复的研究进展()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第2期
页码:
234-238
栏目:
生物材料与力学
出版日期:
2019-02-25

文章信息/Info

Title:
 Research progress on 3D printing technology in retinal repair
文章编号:
1005-202X（2019）02-0234-05
作者:
 谢雨杉1; 汪艳芳1; 黄文华1; 2
 1.南方医科大学基础医学院人体解剖国家重点学科， 广东 广州 510515； 2.广东省医学3D打印应用转化工程技术研究中心， 广东 广州 510515
Author(s):
 XIE Yushan1;  WANG Yanfang1;  HUANG Wenhua1;  2
 1. National Key Discipline, Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; 2. Guangdong Province Medical 3D Printing Application Transformation Engineering Technology Research Center, Guangzhou 510515, China
关键词:
 ; 3D打印; 视网膜细胞; 海藻酸钠水凝胶; 综述
Keywords:
 ; Keywords: three-dimensional printing;  retinal cell;  sodium alginate hydrogel;  review
分类号:
R312
DOI:
DOI:10.3969/j.issn.1005-202X.2019.02.021
文献标志码:
A
摘要:
 生物3D打印技术为视网膜受损修复这一难题的解决提供了可能。用海藻酸钠水凝胶打印一个用于细胞生长的支架，利用3D打印的超高精度将视网膜的神经节细胞和神经胶质细胞植入支架，并加入一定浓度的生长因子，诱导细胞向特性方向生长，用这种方法打印视网膜细胞将实现形态可控、强度可控、梯度释放，有望实现体外视网膜细胞的精确打印，解决临床视网膜神经缺损修复的难题。本文在对这些成果进行系统总结的基础上，简要评析了研究现状并且提出了亟待解决的问题，以期为该领域的进一步研究提供参考。
Abstract:
 Abstract: Biological three-dimensional (3D) printing technology provides the possibility to develop retinal prosthesis. Firstly, sodium alginate hydrogel is used to print a scaffold for cells. And then the ganglion and cells were implant to the scaffold with the use of 3D printing technology with a high accuracy. The growth factors were added into the scaffold to induce the growth of cells. The technology allows the morphology and intensity of cells to be controlled. Moreover, using this technology to print retinal cells can realize gradient release. Herein the achievements of 3D printing technology in retinal repair are summarized; the research status are briefly analyzed; and the existing issues are putted forward, in order to provide a reference for the further research on 3D printing technology in retinal repair.

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备注/Memo

备注/Memo:
 【收稿日期】2018-09-11
【基金项目】国家重点研发计划（2017YFC1103403）；深圳市三名工程（SZSM201612019）
【作者简介】谢雨杉，硕士研究生，研究方向：3D打印，E-mail:2293723919@qq.com
更新日期/Last Update: 2019-02-26