[1]史旭波,黄贵生,苏欢欢,等. 1.5T磁共振功能成像在女性乳腺癌检查中的临床价值及其与Her-2的相关性[J].中国医学物理学杂志,2018,35(12):1441-1446.[doi:DOI:10.3969/j.issn.1005-202X.2018.12.014]
　SHI Xubo,HUANG Guisheng,SU Huanhuan,et al. Clinical values of 1.5T magnetic resonance imaging in detection of female breast cancer and its correlation with Her-2[J].Chinese Journal of Medical Physics,2018,35(12):1441-1446.[doi:DOI:10.3969/j.issn.1005-202X.2018.12.014]
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 1.5T磁共振功能成像在女性乳腺癌检查中的临床价值及其与Her-2的相关性()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第12期
页码:
1441-1446
栏目:
医学影像物理
出版日期:
2018-12-24

文章信息/Info

Title:
 Clinical values of 1.5T magnetic resonance imaging in detection of female breast cancer and its correlation with Her-2
文章编号:
1005-202X（2018）12-1441-06
作者:
 史旭波1; 黄贵生1; 苏欢欢2; 颜剑豪2
 1.揭阳市慈云医院影像中心， 广东 揭阳 522031； 2.广东省第二人民医院影像科， 广东 广州 510317
Author(s):
 SHI Xubo1;  HUANG Guisheng1;  SU Huanhuan2;  YAN Jianhao2
 1. Imaging Center, Jieyang Ciyun Hospital, Jieyang 522031, China; 2. Department of Imaging, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
关键词:
 ; 【关键词】乳腺癌; 磁共振功能成像; 人类表皮生长因子受体-2; 最大线性斜率
Keywords:
 ; Keywords: breast cancer;  magnetic resonance imaging;  human epidermal growth factor receptor-2;  maximum linear slope
分类号:
R445.2；R737.9
DOI:
DOI:10.3969/j.issn.1005-202X.2018.12.014
文献标志码:
A
摘要:
 【摘 要】 目的：探讨1.5T磁共振功能成像在女性乳腺癌检查中的应用价值，并分析其与人类表皮生长因子受体-2（Her-2）的相关性。 方法：纳入揭阳市慈云医院2015年9月~2017年9月收治的经手术病理证实的女性乳腺癌患者60例作为乳腺癌组，并选取同期收治的60例良性乳腺疾病患者作为良性组。所有患者均行1.5T磁共振功能成像检查，比较两组的强化峰值（SImax）、达峰时间（Tpeak）、早期增强率（EER）、最大线性斜率（Slope）。测定两组病灶组织的Her-2 mRNA表达量，分析磁共振功能成像参数与Her-2 mRNA表达水平间的相关性。 结果：乳腺癌组的EER、Slope、Her-2 mRNA表达量高于良性组，SImax、Tpeak低于良性组，组间比较差异有统计学意义（P<0.05）。磁共振成像参数SImax、Tpeak、EER、Slope预测乳腺癌的曲线下面积分别为0.841、0.868、0.846、0.779，其中，Tpeak预测乳腺癌的曲线下面积最大，Slope预测的曲线下面积最小。经Pearson线性相关分析发现SImax、Tpeak与Her-2 mRNA表达量呈负相关（r=0.753、0.701, 均P<0.05），EER、Slope与Her-2 mRNA表达量呈正相关（r=0.810、0.749, 均P<0.05）。 结论：SImax、Tpeak随着Her-2 mRNA表达量降低而增高，EER、Slope随着Her-2 mRNA表达量降低而降低。1.5T磁共振功能成像参数EER、Slope、SImax、Tpeak对乳腺癌的预测均有一定价值，能为乳腺癌的诊断和治疗提供依据。
Abstract:
Abstract: Objective To investigate the application value of 1.5T magnetic resonance imaging (MRI) in the detection of female breast cancer and analyze its correlation with human epidermal growth factor receptor-2 (Her-2). Methods A total of 60 patients with breast cancer confirmed by surgery and pathology in Jieyang Ciyun Hospital from September 2015 to September 2017 were selected as breast cancer group, while 60 cases of benign breast diseases were selected as benign group. All patients underwent 1.5T MRI examination. The maximum signal intensity (SImax), time to peak (Tpeak), early enhancement rate (EER), and maximum linear slope (Slope) were compared between the two groups. The expression levels of Her-2 mRNA in two groups of lesions were measured. The correlation between MRI parameters and Her-2 mRNA expression level was analyzed. Results The expression levels of EER, Slope and Her-2 mRNA in breast cancer group were higher than those in benign group, but SImax and Tpeak were lower in breast cancer group than in benign group, with statistical differences (P<0.05). The area under the curve of SImax, Tpeak, EER and Slope in predicting breast cancer was 0.841, 0.868, 0.846 and 0.779, respectively. Among them, area under the curve of Tpeak in predicting breast cancer was the largest, and the area under the curve predicted by Slope was the smallest. By Pearson linear correlation analysis, it was found that SImax and Tpeak were negatively correlated with Her-2 mRNA expression (r=0.753, 0.701, all P<0.05), and that EER and Slope were positively correlated with Her-2 mRNA expression (r=0.810, 0.749, all P<0.05). Conclusion With the decrease of Her-2 mRNA expression, SImax and Tpeak increase, while ER and Slope decrease. 1.5T MRI parameters, namely EER, Slope, SImax and Tpeak, have certain values in predicting breast cancer, providing the basis for the diagnosis and treatment of breast cancer.

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备注/Memo

备注/Memo:
 【收稿日期】2018-06-25
【基金项目】揭阳市医学科研项目（20176783）
【作者简介】史旭波，副主任医师，研究方向：医学影像学，E-mail: sxb3839@163.com
更新日期/Last Update: 2018-12-26