[1]李晨光,赵晶晶,李正贤,等. Monaco统计噪声参数设置对计算效率和剂量精度的影响[J].中国医学物理学杂志,2018,35(7):766-770.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.005]
　LI Chenguang,ZHAO Jingjing,LI Zhengxian,et al. Effects of different uncertainty settings in Monaco treatment planning system on computation efficiency and dosimetric accuracy[J].Chinese Journal of Medical Physics,2018,35(7):766-770.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.005]
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 Monaco统计噪声参数设置对计算效率和剂量精度的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第7期
页码:
766-770
栏目:
医学放射物理
出版日期:
2018-07-20

文章信息/Info

Title:
 Effects of different uncertainty settings in Monaco treatment planning system on computation efficiency and dosimetric accuracy
文章编号:
1005-202X（2018）07-0766-05
作者:
 李晨光1; 赵晶晶2; 李正贤3; 黎田2; 牛小宇1; 岳海振2
 1.中国海洋大学海洋技术系， 山东 青岛 266100； 2.北京大学肿瘤医院暨北京市肿瘤防治研究所放疗科/恶性肿瘤发病机制及转化研究教育部重点实验室， 北京 100142； 3.吉林国文医院放疗科， 吉林 公主岭 136100
Author(s):
 LI Chenguang1;  ZHAO Jingjing2;  LI Zhengxian3;  LI Tian2;  NIU Xiaoyu1;  YUE Haizhen2
 1. Department of Marine Technology, Ocean University of China, Qingdao 266100, China; 2. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiotherapy, Peking University Cancer Hospital & Institute, Beijing 100142, China; 3. Department of Radiotherapy, Jilin Guowen Hospital, Gongzhuling 136100, China
关键词:
 ; Monaco计划系统; 统计噪声; 计算效率; 剂量精度
Keywords:
 ; Monaco treatment planning system;  uncertainty;  computation efficiency;  dosimetric accuracy
分类号:
R144.1
DOI:
DOI:10.3969/j.issn.1005-202X.2018.07.005
文献标志码:
A
摘要:
 目的：对比Monaco计划系统 Per Calculation（PC）和Per Control Point（PCP）两种统计噪声设置方式的剂量计算精度和计算效率。 方法：选取30例IMRT/VMAT治疗计划，其中胸部和鼻咽部肿瘤各15例，两种噪声统计方式按照剂量计算精度递减的方式分别设置为5组和6组，评估其对计算时间和各剂量学评价指标的影响。 结果：两种噪声统计方式计算时间（s）分别为131.78±26.91、6.76±3.57、1.75±0.57、0.84±0.24、0.84±0.24（PC）和259.20±80.15、73.53±26.00、9.18±3.26、3.60±1.67、1.59±0.75、1.13±0.49（PCP），均与计算精度呈负相关，且差异具有统计学意义（P<0.05）；两组计划各剂量学评价指标箱图分析显示，均值和特定剂量的体积等指标四分位距较小，最大值和全局最大值等评价指标四分位距较大；两组计划各剂量学评价指标单因素ANOVA分析结果无统计学差异（P>0.05）。 结论：两种统计噪声设置方式均可用于临床治疗计划计算精度设置；治疗计划全局最大值与统计噪声正相关，计算时间与统计噪声负相关；不同PC/PCP参数设置对均值和特定剂量的体积等评价影响较小，对全局和串行器官最大值影响较大。
Abstract:
 Abstract: Objective To compare the accuracy and efficiency of dose calculation using two uncertainty settings in Monaco treatment planning system, namely Per Calculation (PC) and Per Control Point (PCP). Methods Thirty intensity-modulated radiotherapy (IMRT) or volumetric modulated arc therapy (VMAT) plans, including 15 for thoracic cancer and 15 for nasopharyngeal carcinoma, were included in this study. According to the decreasing accuracy of dose calculation, 5 groups of PC and 6 groups of PCP, with a total of 11 parameters, were selected in this study. The effects of uncertainty settings on computation time and dosimetric evaluation indicators were evaluated. Results The computation time (s) was 131.780±26.910, 6.76±3.57, 1.75±0.57, 0.84±0.24 and 0.84±0.24 for PC, and 259.20±80.15, 73.53±26.00, 9.18±3.26, 3.60±1.67, 1.59±0.75 and 1.13±0.49 for PCP, respectively. The computation time of PC and PCP was negatively correlated with the accuracy of dose calculation, with statistical significance (P<0.05). The box plot analysis of dosimetric evaluation indicators between two settings showed smaller interquartile ranges among the mean dose and several dose-volume indexes, and larger interquartile ranges in the maximum dose and global maximum dose. Single factor ANOVA analysis of different dosimetric evaluation indicators showed no statistical differences between two uncertainty settings (P<0.05). Conclusion The two uncertainty settings can be used in the clinical treatment planning. The global maximum dose is positively correlated with uncertainty, while the computation time is negatively correlated with uncertainty. PC/PCP settings have marginal effects on the mean dose and specific dose-volume indexes, but significant effects on the global maximum dose and the maximum dose to the serial organs.

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备注/Memo

备注/Memo:
 【收稿日期】2018-04-15
【基金项目】北京市自然科学基金（1174016，7172048，1184014）；国家自然科学基金（11505012）；首都卫生发展科研专项（首发2018-4-1027）；北京大学医学科技创新平台发展基金-青年培育基金（BMU2017PY028，BMU2017PY003）
【作者简介】李晨光，E-mail: 779503913@qq.com
【通信作者】岳海振，硕士，工程师，研究方向：医学物理，E-mail: yuehzh@163.com
更新日期/Last Update: 2018-07-24