[1]欧阳荣珍,孙爱敏,王谦,等. 基于3D打印技术构建仿真儿童CT增强腹部体模的测试研究[J].中国医学物理学杂志,2019,36(3):307-310.[doi:DOI:10.3969/j.issn.1005-202X.2019.03.012]
　OUYANG Rongzhen,SUN Aimin,WANG Qian,et al. Testing research on a realistic pediatric abdominal phantom with CT enhancement constructed with 3D printing technology[J].Chinese Journal of Medical Physics,2019,36(3):307-310.[doi:DOI:10.3969/j.issn.1005-202X.2019.03.012]
点击复制

 基于3D打印技术构建仿真儿童CT增强腹部体模的测试研究()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第3期
页码:
307-310
栏目:
医学影像物理
出版日期:
2019-03-25

文章信息/Info

Title:
 Testing research on a realistic pediatric abdominal phantom with CT enhancement constructed with 3D printing technology
文章编号:
1005-202X（2019）03-0307-04
作者:
 欧阳荣珍1; 孙爱敏1; 王谦1; 郭辰1; 李剑颖2; 胡立伟1; 钟玉敏1
 1.上海交通大学医学院附属上海儿童医学中心放射科， 上海 200127； 2.GE中国CT影像研究中心， 上海 201203
Author(s):
 OUYANG Rongzhen1;  SUN Aimin1;  WANG Qian1;  GUO Chen1;  LI Jianying2;  HU Liwei1;  ZHONG Yumin1
 1. Department of Radiology, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China; 2. CT Research Center of GE, Shanghai 201203, China
关键词:
 ; 3D打印技术; CT; 腹部体膜; 儿童
Keywords:
 ; Keywords: 3D printing technology;  computed tomography;  abdominal phantom;  pediatric
分类号:
R318
DOI:
DOI:10.3969/j.issn.1005-202X.2019.03.012
文献标志码:
A
摘要:
 目的：本研究构建仿真的儿童CT增强腹部体模，并验证其解剖结构的CT衰减特性与正常儿童腹部增强CT图像质量比较。方法：基于3D打印直写成型技术，将聚氨酯和三（2-氯乙基）磷酸酯（TCEP）作为混合的打印材料。使用不同浓度的TCEP（0%~60%）混合材料，在不同管电压下（80~120 kV），评价TCEP混合材料浓度和CT值的线性关系。根据患者CT影像数据设计并打印仿真动脉期儿童CT增强腹部体模。体模在CT下重复3次扫描以评估数据一致性。将仿真CT图像与正常儿童的CT图像比较，对肝脏、腹主动脉、肾皮质、脾脏和肌肉的CT值、图像噪声、对比噪声比（CNR）进行计算和客观评价。采用5分制，由两个放射科医生对图像质量进行主观评价。结果：在不同的管电压下，TCEP浓度变化和CT值之间都存在良好的线性关系（P<0.001, r=0.99）。除了腹主动脉 ，仿真体模各解剖结构CT值与正常儿童一致（P>0.05）。肝脏、肾皮质和脾脏的体模图像比正常儿童的图像有更高的CNR值（7.08±0.83 vs 5.50±0.48、14.18±2.48 vs 10.67±1.05、11.84±1.69 vs 8.78±0.53）。仿真体模CT图像噪声相比于正常儿童基本一致［（12.3±1.47） HU vs (13.7±1.5） HU］。但主观图像质量评分略低（4.35±0.17 vs 4.72±0.17、4.50±0.16 vs 4.65±0.12）。结论：研究证明通过3D打印直写成型技术构建仿真体模具有可行性，且图像质量和一致性良好。仿真的儿童CT体模能模拟不同患者体型的组织衰减特性，可用于优化CT剂量和重建算法。
Abstract:
 Abstract: Objective To construct a realistic pediatric abdominal phantom with CT enhancement, and validate its X-ray attenuation properties by comparing phantom images with the enhanced abdominal CT images of normal children. Methods Based on the rapid prototyping of 3D printing technology, polyurethane and tris (2-chloroethy) phosphate (TCEP) were used as printing materials. The TCEP mixed materials of different concentrations (0%-60%) was used to investigate the linear relationships between the concentration of TCEP mixed materials and CT values at different tube voltages (80-120 kV). According to the CT imaging data of the patient, a pediatric abdominal phantom with CT enhancement in the arterial phase was designed and printed. The printed phantom was scanned with CT for 3 times to assess the reproducibility. And then the phantom CT images were compared with the CT images of normal children. The CT values, image noises and contrast-to-noise ratios of liver, abdominal aorta, kidney cortex, spleen and muscle were measured. Finally, the subjective image quality was assessed by two radiologists using a 5-point scale. Results A good linear relationship was found between CT value and TCEP concentration at all tube voltages (P<0.001, r=0.99). The CT values of all tissues were similar between phantom and normal children (all P>0.05), except for the CT value of abdominal aorta. The contrast-to-noise ratios of liver, kidney cortex and spleen in phantom images were higher than those in the images of normal children (7.08±0.83 vs 5.50±0.48, 14.18±2.48 vs 10.67±1.05, and 11.84±1.69 vs 8.78±0.53, respectively). The phantom images and CT images of normal children had similar image noise ［(12.3±1.47) HU vs (13.7±1.5) HU］. However, the subjective image quality scores of phantom images were slightly lower (4.35±0.17 vs 4.72±0.17, 4.50±0.16 vs 4.65±0.12). Conclusion Using the rapid prototyping of 3D printing technology to construct realistic phantom is proved to be feasible. The phantom image has a high quality and consistent attenuation characteristics. The realistic pediatric phantom can be used to simulate the attenuation characteristics of patients of different body shapes, so as to optimize dose distribution and reconstruction algorithms.

相似文献/References:

[1]胡立伟,钟玉敏.3D打印技术在儿童先天性心脏病诊断及治疗中的应用进展[J].中国医学物理学杂志,2015,32(04):514.[doi:10.3969/j.issn.1005-202X.2015.04.014]
[2]胡立伟,钟玉敏,王谦,等.3D打印技术：一种认识先天性心脏病的新方法[J].中国医学物理学杂志,2016,33(2):173.[doi:10.3969/j.issn.1005-202X.2016.02.013]
[3]王遥,霍万里,熊壮,等.TACE手术中不同站姿下铅眼镜和铅面罩对医生眼晶状体防护效果的蒙特卡洛模拟比较[J].中国医学物理学杂志,2016,33(6):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
　[J].Chinese Journal of Medical Physics,2016,33(3):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
[4]张新,谷晓芳,王培臣,等.轻离子束治疗设备注册检验关键技术问题[J].中国医学物理学杂志,2016,33(6):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
　[J].Chinese Journal of Medical Physics,2016,33(3):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
[5]江芬芬,王培,康盛伟,等. 热释光剂量片测量肺部肿瘤放疗剂量的方法[J].中国医学物理学杂志,2016,33(6):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
　[J].Chinese Journal of Medical Physics,2016,33(3):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
[6]刘洪源,彭威,杨锐,等. 锥形束CT离线校正肺癌摆位误差[J].中国医学物理学杂志,2016,33(6):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
　[J].Chinese Journal of Medical Physics,2016,33(3):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
[7]赵彪,潘香,杨毅,等. 右乳癌保乳术后瘤床同步X线和后程电子线补量调强放疗剂量学比较[J].中国医学物理学杂志,2016,33(6):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
　[J].Chinese Journal of Medical Physics,2016,33(3):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
[8]邓南,钱建庭,刁现芬,等. 基于宽带检测放疗X-光光声效应仿体实验[J].中国医学物理学杂志,2016,33(9):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
　[J].Chinese Journal of Medical Physics,2016,33(3):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
[9]张先稳,李军,张西志,等. 宫颈癌术后5野调强放疗4个变量组合的最佳治疗模式的剂量学[J].中国医学物理学杂志,2016,33(9):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
　[J].Chinese Journal of Medical Physics,2016,33(3):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
[10]胡健,李承军,徐利明,等. 床面倾斜对剂量验证通过率的影响[J].中国医学物理学杂志,2016,33(9):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
　[J].Chinese Journal of Medical Physics,2016,33(3):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
[11]胡立伟,白凯,钟玉敏,等. 基于不同图像分割法构建3D打印右室双出口模型[J].中国医学物理学杂志,2016,33(12):1272.[doi:10.3969/j.issn.1005-202X.2016.12.020]
　[J].Chinese Journal of Medical Physics,2016,33(3):1272.[doi:10.3969/j.issn.1005-202X.2016.12.020]
[12]姚小芬,钟玉敏,胡立伟,等. 三维打印技术在狭颅症矫治手术中的应用[J].中国医学物理学杂志,2017,34(4):423.[doi:DOI:10.3969/j.issn.1005-202X.2017.04.020]
[13]苏炜炜,谢普生,谭晋川,等. 3D打印技术在骨科的应用研究[J].中国医学物理学杂志,2019,36(2):245.[doi:DOI:10.3969/j.issn.1005-202X.2019.02.023]
　SU Weiwei,XIE Pusheng,TAN Jinchuan,et al.Application of 3D printing technology in orthopaedics[J].Chinese Journal of Medical Physics,2019,36(3):245.[doi:DOI:10.3969/j.issn.1005-202X.2019.02.023]

备注/Memo

备注/Memo:
 【收稿日期】2018-09-25
【基金项目】十三五科技部重大专项“增材制造与激光制造”子课题（2018YFB1107105）；上海市级医院新兴前沿技术项目（SHDC12015128）；上海市科学技术委员会重点项目（17DZ1930505）
【作者简介】欧阳荣珍，硕士，住院医师，研究方向：儿童先天性心脏病影像诊断，E-mail: oyrzhen@163.com
【通信作者】胡立伟，硕士，主管技师，研究方向：生物医学工程、3D打印技术，E-mail: huliwei11@hotmail.com
更新日期/Last Update: 2019-03-25