[1]周永军,张辉,牛中奇. 极低频电磁暴露对钙离子跨膜迁移的影响及机理分析[J].中国医学物理学杂志,2019,36(1):112-116.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.022]
　ZHOU Yongjun,ZHANG Hui,NIU Zhongqi.Effects of extremely low frequency electromagnetic exposure on calcium ion transmembrane migration and mechanism analysis[J].Chinese Journal of Medical Physics,2019,36(1):112-116.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.022]
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 极低频电磁暴露对钙离子跨膜迁移的影响及机理分析()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第1期
页码:
112-116
栏目:
医学生物物理
出版日期:
2019-01-25

文章信息/Info

Title:
Effects of extremely low frequency electromagnetic exposure on calcium ion transmembrane migration and mechanism analysis
文章编号:
1005-202X（2019）01-0112-05
作者:
 周永军1; 张辉1; 牛中奇2
 1.咸阳师范学院物理与电子工程学院， 陕西 咸阳 712000； 2.西安电子科技大学电子工程学院， 陕西 西安 710071
Author(s):
ZHOU Yongjun1;  ZHANG Hui1;  NIU Zhongqi2
 1. School of Physics and Electronic Engineering, Xianyang Normal University, Xianyang 712000, China; 2. School of Electric Engineering, Xidian University, Xi’an 710071, China
关键词:
 ; 极低频电磁暴露; 钙离子; 跨膜迁移; 影响; 机理
Keywords:
 ; Keywords: extremely low frequency electromagnetic exposure;  calcium ion;  transmembrane migration;  influence;  mechanism
分类号:
R318
DOI:
DOI:10.3969/j.issn.1005-202X.2019.01.022
文献标志码:
A
摘要:
 目的：研究极低频（ELF）电磁暴露对细胞钙离子跨膜迁移的影响。 方法：以人体肝癌细胞为对象，激光扫描共聚焦显微镜为检测手段，研究细胞钙离子跨膜迁移对ELF电磁暴露的响应。 结果：在磁场强度为1.78×10-7 T条件下，与对照组对比，各暴露组均对不同频率和电场强度组合的外加电磁暴露环境有响应，其中[f=16 Hz]且[EP=53 Vm]、[f=45 Hz]且[EP=53 Vm]以及[f=16 Hz]且[EP=80 Vm]的电磁暴露可使钙离子跨膜迁移量显著上升，而[f=32 Hz]且[EP=53 Vm]、[f=60 Hz]且[EP=53 Vm]、[f=16 Hz]且[EP=26 Vm]以及[f=16 Hz]且[EP=87 Vm]的电磁暴露未使钙离子跨膜迁移量显著上升。 结论：不同频率和电场强度组合的ELF电磁暴露均会引起钙离子跨膜迁移量产生变化且呈现出明显差异，这可为ELF电磁环境下生物学应用提供实验依据；注重细胞膜离子通道物理、生物特性基础上探讨ELF电磁暴露对钙离子跨膜迁移影响的机理。
Abstract:
 Abstract: Objective To study the effects of extremely low frequency (ELF) electromagnetic exposure on calcium ion transmembrane migration. Methods The human hepatoma cells were taken as the subjects in this study. The responses of calcium ion transmembrane migration to ELF electromagnetic exposure were detected by laser scanning confocal microscopy. Results Under the condition that the magnetic field strength remained at 1.78×10-7 T, the transmembrane migration of calcium ion in exposure groups was responded to the applied electromagnetic exposure environment with different properties. With the frequency (f) of 16 Hz or 45 Hz and electric field peak (EP) of 53 V/m, f of 16 Hz and EP of 80 V/m, the ELF electromagnetic exposure made calcium ion transmembrane migration increased significantly, while calcium ion transmembrane migration wasn’t increased significantly under the exposure with f of 32 Hz or 60 Hz and EP of 53 V/m, f of 16 Hz and EP of 26 V/m or 87 V/m. Conclusion The combination of different frequencies and electric field peaks of ELF electromagnetic exposure can increase calcium ion transmembrane migration, and the differences are significant, which provides experimental basis for the biological application of ELF electromagnetic exposure. The mechanism of the effects of ELF electromagnetic exposure on calcium ion transmembrane migration should be discussed based on the physical and biological characteristics of cell membrane ion channels.

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备注/Memo

备注/Memo:
 【收稿日期】2018-07-17
【基金项目】陕西省科技研究发展计划项目（2016JM6053）；陕西省教育厅专项科研计划项目（18JK0831）；咸阳师范学院科研基金项目（14XSYK009）；咸阳师范学院教改项目（201402010）；陕西省大学生创新创业训练计划项目（2510）；咸阳师范学院创新创业训练计划项目（2017079）；咸阳师范学院科研项目（XSYK18094）
【作者简介】周永军，副教授，研究方向：电磁场与微波技术，E-mail: hoozyj@tom.com
更新日期/Last Update: 2019-01-25