[1]杨骏,张海生,金贵,等.基于磁感应的闭合性颅脑撞击伤脑出血早期检测实验研究[J].中国医学物理学杂志,2018,35(9):1069-1074.[doi:10.3969/j.issn.1005-202X.2018.09.014]
　YANG Jun,ZHANG Haisheng,JIN Gui,et al.Experimental research of early detection of cerebral hemorrhage in closed craniocerebralinjury based on magnetic induction[J].Chinese Journal of Medical Physics,2018,35(9):1069-1074.[doi:10.3969/j.issn.1005-202X.2018.09.014]
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基于磁感应的闭合性颅脑撞击伤脑出血早期检测实验研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第9期
页码:
1069-1074
栏目:
医学生物物理
出版日期:
2018-09-27

文章信息/Info

Title:
Experimental research of early detection of cerebral hemorrhage in closed craniocerebral injury based on magnetic induction
文章编号:
1005-202X（2018）09-1069-06
作者:
杨骏; 张海生; 金贵; 陈明生; 秦明新
陆军军医大学生物医学工程与影像医学学院，重庆400038
Author(s):
YANG Jun;  ZHANG Haisheng;  JIN Gui;  CHEN Mingsheng;  QIN Mingxin
College of Biomedical Engineering and Medical Imaging, Army Military Medical University, Chongqing 400038, China
关键词:
合性颅脑出血; 磁感应相位移; 非接触; 无创; 撞击
Keywords:
closed cerebral hemorrhage;  magnetic induction phase shift;  non-contact;  noninvasive;  impact
分类号:
R318.6；R642
DOI:
10.3969/j.issn.1005-202X.2018.09.014
文献标志码:
A
摘要:
目的：基于磁感应相位移（Magnetic Induction Phase Shift, MIPS）方法建立一种早期、非接触、无创的闭合性颅脑 出血（Closed Cerebral Hemorrhage, CCH）检测系统，利用MIPS的变化随脑组织电导率变化而变化的关系，对家兔是否存 在CCH进行检测判别。方法：通过撞击仪对家兔头部顶骨撞击致伤。随后在1 h内对家兔头部进行CT断层平扫，8 h后 取出大脑大体进行病理切片HE染色，验证家兔在致伤后是否存在CCH。最后用自制MIPS检测系统采集家兔在致伤前 和致伤后0~10 min内的MIPS信号，再对其进行处理、分析。结果：在动物致伤模型上，CT与病理实验结果显示家兔受撞 击致伤后出现CCH。在检测实验上，家兔在特征频率下致伤前后的MIPS变化值为（27.168 76±6.582 64）°，且致伤后的 MIPS随病情发展先出现微小下降，再出现缓慢上升的变化趋势。结论：在早期阶段，MIPS在检测过程中能判别出现 CCH的家兔，并且能较好地反映CCH变化情况。
Abstract:
Objective To establish a magnetic induction phase shift (MIPS)-based system for early, non-contact and noninvasive detection of closed cerebral hemorrhage (CCH), and to determine whether the rabbit has CCH utilizing the relationship between MIPS and electrical conductivity of the brain tissues. Methods Impact injury on the parietal bone in rabbits was caused by an impactor. In 1 hour after injury, CT scan was performed on the head of rabbits. At 8 hours after injury, the brain was taken out for pathological section HE staining to verify the existence of CCH after injury in rabbits. Finally, the homemade MIPS detection system was used to collect the MIPS signals in the rabbits before injury and within 0 to 10 minutes after injury. The obtained MIPS signals were then processed and analyzed. Results In the animal model, the results of CT and pathological experiment verified the existence of CCH after impact injury in rabbits. In the detection experiment, the change of MIPS before and after injury in rabbits was (27.168 76+6.582 64)° at the characteristic frequency. Moreover, with the development of the condition after injury, the trend of MIPS appeared a tiny drop first and then slowly rising. Conclusion In the early stage, MIPS system can not only differentiate rabbits with CCH during the test, but also reflect the change of CCH better.

相似文献/References:

[1]李根,孙建,秦明新,等.家兔脑出血脑磁感应相位移与颅内压变化的相关性[J].中国医学物理学杂志,2015,32(05):650.[doi:doi:10.3969/j.issn.1005-202X.2015.05.008]
[2]段海军,金贵,白泽霖,等. 磁感应方法测量家兔脑出血过程中的拐点[J].中国医学物理学杂志,2017,34(11):1150.[doi:DOI:10.3969/j.issn.1005-202X.2017.11.013]
　DUAN Haijun,JIN Gui,BAI Zelin,et al. Turning point during the intracerebral hemorrhage of rabbit monitored with magnetic induction method[J].Chinese Journal of Medical Physics,2017,34(9):1150.[doi:DOI:10.3969/j.issn.1005-202X.2017.11.013]

备注/Memo

备注/Memo:
【收稿日期】2018-03-15 【基金项目】国家自然科学基金（61372065）；军队医学科技青年培育项 目（15QNP060） 【作者简介】杨骏，硕士研究生，E-mail: 286567562@qq.com 【通信作者】秦明新，教授，博士生导师，E-mail: 346709149@qq.com；陈 明生，讲师，E-mail: chenms83@163.com（秦明新与陈明生为 共同通信作者）
更新日期/Last Update: 2018-09-28