[1]王丽,贺春林,郑鑫,等. 基于Monte Carlo算法的精原细胞瘤术后两种放疗技术的剂量学比较[J].中国医学物理学杂志,2018,35(8):905-908.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.008]
　WANG Li,HE Chunlin,et al. Dosimetric comparison of two postoperative radiotherapy techniques for seminoma based on Monte Carlo algorithm[J].Chinese Journal of Medical Physics,2018,35(8):905-908.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.008]
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 基于Monte Carlo算法的精原细胞瘤术后两种放疗技术的剂量学比较()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第8期
页码:
905-908
栏目:
医学放射物理
出版日期:
2018-08-20

文章信息/Info

Title:
 Dosimetric comparison of two postoperative radiotherapy techniques for seminoma based on Monte Carlo algorithm
文章编号:
1005-202X（2018）08-0905-04
作者:
 王丽1; 2; 贺春林1; 郑鑫1; 陈敏治1; 赖庆宽1; 任杰2
 
1.西华师范大学计算机学院， 四川 南充 637000； 2.南充市中心医院， 四川 南充 637000
Author(s):
 WANG Li1;  2;  HE Chunlin1;  ZHENG Xin1;  CHEN Minzhi1;  LAI Qingkuan1;  REN Jie2
 1. School of Computing, China West Normal University, Nanchong 637000, China; 2. Nanchong Central Hospital, Nanchong 637000, China
关键词:
精原细胞瘤; 三维适形放疗; 调强放疗; 剂量学; Monte Carlo算法
Keywords:
 ; Keywords: seminoma;  three-dimensional conformal radiotherapy;  intensity-modulated radiotherapy;  dosimetry;  Monte Carlo algorithm
分类号:
R730.55；R737.9
DOI:
DOI:10.3969/j.issn.1005-202X.2018.08.008
文献标志码:
A
摘要:
 【摘 要】 目的：比较精原细胞瘤经腹股沟高位睾丸切除术后基于Monte Carlo算法的两种放疗技术的剂量学差异，探讨两种技术在改善靶区剂量和保护危及器官等方面的优势。 方法：针对24例精原细胞瘤术后放疗患者定位图像分别设计三维适形放疗（3DCRT）计划和调强放疗（IMRT）计划，满足90%PTV处方剂量32.4 Gy/1.8 Gy/18 f。对比并分析两组计划的靶区和危及器官剂量学参数、机器跳数等差异。 结果：IMRT计划的靶区适形度和均匀性均优于3DCRT计划，IMRT计划的D2、V105%、V110%均远小于3DCRT计划（P<0.05），而3DCRT计划中的D98低于IMRT计划（P<0.05）。对于危及器官，IMRT计划中脊髓Dmean、D2、V20，左肾D98、V10、V20，右肾Dmean、D2、D98、V10、V20、V30，小肠Dmean、D2，膀胱D98、V10，股骨头Dmean、D98、V10、V20、V30均低于3DCRT计划（P<0.05）。3DCRT计划的肝脏Dmean、D2、V20、V30以及小肠V20均低于IMRT计划（P<0.05）。3DCRT与IMRT计划的机器跳数均值分别为256、947 MU。 结论：对于精原细胞瘤术后辅助放疗，3DCRT和IMRT均能满足临床需要，但IMRT技术在靶区剂量分布和对脊髓、肾、膀胱、股骨头的保护方面比3DCRT有更多的优势，而3DCRT技术在对肝脏的保护方面更有优势，且降低了机器损耗减轻了放疗技术员工作负担。
Abstract:
 Abstract: Objective To compare the dosimetric differences between two radiotherapy technologies based on Monte Carlo algorithm for siminoma after inguinal high testicle excision, and investigate the advantages of the two technologies in improving the target dose and protecting the organs-at-risk (OAR). Methods According to the localization images of 24 patients undergoing postoperative radiotherapy for seminoma, 2 plans were designed for each patient, namely three-dimensional conformal radiotherapy (3DCRT) plan and intensity-modulated radiotherapy (IMRT) plan, with 90% planning target volume receiving the prescription dose of 32.4 Gy/1.8 Gy/18 f. The differences in dosimetry parameters of target areas and OAR, and monitor units were compared and analyzed. Results The target conformability and homogeneity of IMRT plan were better than those of 3DCRT plan (P<0.05). The D2, V105%,V110% of target areas were lower in IMRT plan as compared with those in 3DCRT plan (P<0.05), while the D98 of target areas in 3DCRT plan was lower than that in IMRT plan (P<0.05). Several OAR dose parameters in IMRT plan were lower those in 3DCRT plan (P<0.05), including the Dmean, D2, V20 of spinal cord, the D98, V10, V20 of left kidney, the Dmean, D2, D98, V10, V20, V30 of right kidney, the Dmean, D2 of small bowel, the D98, V10 of bladder, and the Dmean, D98, V10, V20, V30 of femoral head. However, the Dmean, D2, V20, V30 of liver and the V20 of small bowel in 3DCRT plan were lower than those in IMRT plan (P<0.05). The average monitor units of 3DCRT plan and IMRT plan were 256 and 947 MU, respectively. Conclusion As adjuvant radiotherapy after inguinal high testicle excision for seminoma, both 3DCRT and IMRT meet the clinical needs. Compared with 3DCRT, IMRT has advantages in target dose distribution, and the protection of spinal cord, kidney, bladder and femoral head. However, 3DCRT has more advantages in protecting liver, while reducing monitor loss and work burden of technicians.

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备注/Memo

备注/Memo:
 【收稿日期】2018-02-23
【作者简介】王丽，研究生，工程师，研究方向：计算机应用及肿瘤放疗物理技术，E-mail: wanglytg@163.com
【通信作者】贺春林，教授，研究方向：计算机模式识别及图形图像处理，E-mail: chunlin_he@163.com
更新日期/Last Update: 2018-07-26