[1]缪洪涛,马诗静,全红,等. FePt/GO纳米复合材料在放化疗中的应用[J].中国医学物理学杂志,2018,35(5):612-615.[doi:DOI:10.3969/j.issn.1005-202X.2018.05.021]
　MIAO Hongtao,MA Shijing,QUAN Hong,et al. Application of FePt/GO nanocomposites in chemoradiotherapy[J].Chinese Journal of Medical Physics,2018,35(5):612-615.[doi:DOI:10.3969/j.issn.1005-202X.2018.05.021]
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 FePt/GO纳米复合材料在放化疗中的应用()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第5期
页码:
612-615
栏目:
生物材料与力学
出版日期:
2018-05-22

文章信息/Info

Title:
 Application of FePt/GO nanocomposites in chemoradiotherapy
文章编号:
1005-202X（2018）05-0612-04
作者:
 缪洪涛1; 马诗静2; 全红1; 谢丛华2
 1.武汉大学物理科学与技术学院， 湖北 武汉 430072； 2.武汉大学中南医院放疗科， 湖北 武汉 430071
Author(s):
 MIAO Hongtao1;  MA Shijing2;  QUAN Hong1;  XIE Conghua2
 1. School of Physics and Technology, Wuhan University, Wuhan 430072, China; 2. Department of Radiation Oncology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
关键词:
 ; FePt/GO纳米复合材料; 放射增敏; 细胞毒性; 放化疗
Keywords:
 ; FePt/GO nanocomposites;  radiosensitization;  cytotoxicity;  chemoradiotherapy
分类号:
R312；Q691.5
DOI:
DOI:10.3969/j.issn.1005-202X.2018.05.021
文献标志码:
A
摘要:
目的：探索FePt/GO纳米复合材料的抗肺癌效果。 方法：通过化学还原的方法制备出径粒约为3 nm的FePt纳米颗粒，并通过超声将FePt纳米颗粒装载于氧化石墨烯（GO）表面得到FePt/GO纳米复合材料，运用TEM、AFM、XPS等技术对其进行表征。将得到FePt/GO纳米复合材料分别与非小细胞肺癌细胞（H1975）和人胚肺成纤维细胞（HELF）共同培养，用CCK-8法对其进行毒性评估；通过单细胞克隆形成实验与CCK-8法评估FePt/GO复合纳米材料的放射增敏作用。 结果：成功制备出FePt/GO纳米复合材料，在一定浓度范围内，FePt/GO对H1975细胞表现出很明显的毒性而对正常HELF细胞无明显毒性，并且可以有效地增强X射线对H1975细胞的杀伤作用。 结论：FePt/GO纳米复合材料是一种有可能用于临床的抗癌药物。
Abstract:
 Abstract: Objective To explore the potential anticancer effect of FePt/graphene oxide (FePt/GO) nanocomposites in lung cancer. Methods FePt nanoparticles with particle size of about 3 nm were prepared by a chemical reduction method, and FePt/GO nanocomposites were facilely produced by assembling FePt nanoparticles to the surface of GO through sonicate. Transmission electron microscope, atom force microscope and X-ray photoelectron spectroscopy were utilized to characterize the surface morphology and chemical composition of FePt/GO nanocomposites. The obtained FePt/GO nanocomposites were cultured with non small cell lung cancer cells (H1975 cells) and Human embryonic lung fibroblasts (HELF cells), separately, and the cytotoxicity of FePt/GO nanocomposites was evaluated in H1975 cells and HELF cells by CCK-8 assay. The radiosensitization ability of FePt/GO nanocomposites was determined by colony formation test and CCK-8 assay. Results FePt/GO nanocomposites were successfully prepared in this study. Within a certain concentration range, FePt/GO nanocomposites showed significant toxicity to H1975 cells, while keeping no obvious toxicity to HELF cells. Furthermore, FePt/GO nanocomposites enhanced the suppression of X-ray on H1975 cells growth. Conclusion FePt/GO nanocomposite is a potential anticancer agent which could be used in clinical treatment.

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备注/Memo

备注/Memo:
 【收稿日期】2018-01-25
【基金项目】国家自然科学基金（81572967）；医科达-武汉大学医学物理教学科研基金（250000200）
【作者简介】缪洪涛，硕士在读，研究方向：纳米材料制备、纳米材料在放化疗中的应用，E-mail: 744512027@qq.com
【通信作者】全红，副教授，博士生导师，研究方向：放射治疗、医学影像，E-mail: 00007962@whu.edu.cn
更新日期/Last Update: 2018-05-22