[1]张金丽,程云章,郑淇文.连续型血泵溶血性能评价方法分析[J].中国医学物理学杂志,2018,35(9):1087-1093.[doi:10.3969/j.issn.1005-202X.2018.09.017]
　ZHANG Jinli,CHENG Yunzhang,ZHENG Qiwen.Analysis of hemolytic performance of continuous blood pump[J].Chinese Journal of Medical Physics,2018,35(9):1087-1093.[doi:10.3969/j.issn.1005-202X.2018.09.017]
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连续型血泵溶血性能评价方法分析()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第9期
页码:
1087-1093
栏目:
医学生物物理
出版日期:
2018-09-27

文章信息/Info

Title:
Analysis of hemolytic performance of continuous blood pump
文章编号:
1005-202X（2018）09-1087-07
作者:
张金丽1; 程云章1; 郑淇文2
1.上海理工大学医疗器械与食品学院，上海200093；2.丰凯医疗器械（上海）有限公司，上海201138
Author(s):
ZHANG Jinli1;  CHENG Yunzhang1;  ZHENG Qiwen2
1. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; 2. ForQaly Medical (Shanghai) Company Limited, Shanghai 201138, China
关键词:
续型血泵; 溶血; 计算流体力学; 溶血实验
Keywords:
continuous blood pump;  hemolysis;  computational fluid dynamics;  hemolysis experiment
分类号:
R318.6
DOI:
10.3969/j.issn.1005-202X.2018.09.017
文献标志码:
A
摘要:
溶血性能是影响血泵可靠性的主要因素之一。对溶血性能的有效评价，为血泵的设计和改进提供有力依据。本 文对血泵研究和开发中进行溶血评价的方法进行综述，包括溶血估算和溶血实验。文章首先阐述了溶血估算，包括数值 估算模型和基于计算流体力学技术的溶血分析；然后介绍有模型样机之后的溶血实验，包括体外循环模拟实验以及动物 实验。其次对比分析两种方法的优势与局限性，并得出相关结论：溶血估算适用于血泵研发前期，溶血实验适用于中后期 已有模型样机后的溶血评价；溶血估算为溶血实验奠定了基础，溶血实验验证了溶血估算的结果；溶血实验研究与数值估 算相互联系、相互促进，但不能完全替代；针对不同的研究者和研究机构，应根据自身条件选择合适的评价方法。最后讨 论血泵溶血评估领域存在的问题以及发展趋势。
Abstract:
Hemolytic performance is one of the main factors affecting the reliability of blood pump. Effective evaluation of hemolytic performance provides a strong basis for the design and improvement of blood pump. Herein, the commonly used methods for hemolysis evaluation in the research and development of blood pump were summarized, including hemolysis estimation and hemolysis experiment. Firstly, the hemolysis estimation was described, including the theoretical numerical estimation model and the hemolysis analysis based on the computational fluid dynamics technique. After the model prototype was developed, the hemolysis experiments were introduced, including cardiopulmonary bypass simulation and animal experiment. Secondly, the advantages and limitations of the two methods were compared, and the comparison results showed that hemolysis estimation was preferred in the pre-development of blood pump, while hemolysis experiment was suitable for hemolytic evaluation with model prototype in the middle and later stages. The hemolysis estimation laid the foundation for hemolysis experiment which verified the results of hemolysis estimation. The hemolysis experiment and numerical estimation were mutual connection and mutual promotion, but they could not be completely replaced. Different researchers and research institutes should choose the appropriate evaluation method according to their own conditions. Finally, the problems and the development trends in the evaluation of blood pump hemolysis were discussed.

相似文献/References:

[1]张伟国,程云章,胡 平,等.离心血泵内部流场数字模拟及溶血分析[J].中国医学物理学杂志,2014,31(02):4814.[doi:10.3969/j.issn.1005-202X.2014.02.022]
[2]唐洁,程云章,郑淇文,等.介入式微型轴流血泵溶血机理及影响因素分析[J].中国医学物理学杂志,2020,37(3):368.[doi:DOI:10.3969/j.issn.1005-202X.2020.03.021]
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备注/Memo

备注/Memo:
【收稿日期】2018-04-11 【基金项目】微创励志创新基金（YS30809135） 【作者简介】张金丽，硕士，主要研究方向：数值模拟，E- mail: jlzhang@forqaly.com 【通信作者】程云章，教授，博士生导师，主要从事血流动力学及其临 床应用、精准医疗科学与工程、医疗器械大数据应用等， E-mail: cyz2008@usst.edu.cn
更新日期/Last Update: 2018-09-28