[1]潘文才,种银保,秦明新,等.失血性休克脑血流低灌注磁感应相移检测的实验研究[J].中国医学物理学杂志,2018,35(6):707-713.[doi:DOI:10.3969/j.issn.1005-202X.2018.06.016]
　PAN Wencai,CHONG Yinbao,QIN Mingxin,et al. Experimental study of cerebral hypoperfusion in hemorrhagic shock using magnetic induction phase shift method[J].Chinese Journal of Medical Physics,2018,35(6):707-713.[doi:DOI:10.3969/j.issn.1005-202X.2018.06.016]
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失血性休克脑血流低灌注磁感应相移检测的实验研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第6期
页码:
707-713
栏目:
医学生物物理
出版日期:
2018-06-22

文章信息/Info

Title:
 Experimental study of cerebral hypoperfusion in hemorrhagic shock using magnetic induction phase shift method
文章编号:
1005-202X（2018）06-0707-07
作者:
 潘文才1; 种银保1; 秦明新2; 庄伟2; 马结实1; 赵鹏1
 1.陆军军医大学第二附属医院医学工程科， 重庆 400037； 2.陆军军医大学生物医学工程系电子工程学教研室， 重庆 400038
Author(s):
 PAN Wencai1;  CHONG Yinbao1;  QIN Mingxin2;  ZHUANG Wei2;  MA Jieshi1;  ZHAO Peng1
 1. Department of Medical Engineering, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, China; 2. Department of Electronic Engineering, School of Biomedical Engineering, Army Medical University, Chongqing 400038, China
关键词:
】磁感应相移; 脑血流灌注; 失血性休克; 动脉血乳酸; 激光多普勒
Keywords:
 ; Keywords: magnetic induction phase shift;  cerebral blood perfusion;  hemorrhagic shock;  arterial blood lactate;  laser Doppler
分类号:
R318
DOI:
DOI:10.3969/j.issn.1005-202X.2018.06.016
文献标志码:
A
摘要:
 磁感应相移（MIPS）技术以检测生物组织介电特性为基础，具有非接触、无创、可连续监测等优点，是检测脑缺血非常有效的方法。为验证MIPS技术检测失血性休克脑血流低灌注的有效性，本研究在自研的MIPS检测系统上对20只家兔失血性休克模型进行脑血流灌注检测，同时采用动脉血乳酸（ABL）以及激光多普勒（LDF）脑血流值作为对照指标。选取19只家兔实验数据纳入统计分析。结果显示随着失血性休克发生，脑血流灌注MIPS值由基线（0°）下降到（-5.28±1.99）°，ABL浓度由（3.55±2.24） mmol/L上升到（13.34±6.66） mmol/L，LDF脑血流值基线百分比由100%下降到（59.26±51.57）%，脑血流灌注MIPS值与ABL浓度具有很高的相关性（相关系数均大于0.816），且MIPS测量值较LDF测量值具有更好的分辨力。结果表明MIPS技术能有效检测失血性休克脑血流低灌注，采用脑血流灌注MIPS指标作为院前检测失血性休克具有可行性。
Abstract:
 Abstract: Magnetic induction phase shift (MIPS) technology which is based on the dielectric properties of biological tissues is a non-contact and noninvasive method for continuous monitoring. The feasibility of using MIPS for cerebral ischemia detection has been proved. In order to verify whether MIPS technology can effectively detect cerebral hypoperfusion in hemorrhagic shock, the cerebral hypoperfusion MIPS values of 20 rabbits with hemorrhagic shock were detected by homemade MIPS detection system, while the arterial blood lactate (ABL) and laser Doppler (LDF) values of the cerebral blood flow were used as references. The experimental data of 19 rabbits were selected for statistic analysis. The results revealed that with the development of hemorrhagic shock, the cerebral perfusion MIPS value reduced from the baseline (0°) to (-5.28±1.99)°; and that ABL concentration increased from (3.55±2.24) mmol/L to (13.34±6.66) mmol/L; and that the baseline percentage of cerebral blood flow LDF value decreases from 100% to (59.26±51.57)%. The cerebral perfusion MIPS value was proved to be highly correlated with ABL concentration, with all correlation coefficients greater than 0.816, and meanwhile MIPS measurement had better detection resolutions than LDF measurement. The above results show that the MIPS technology can effectively detect cerebral hypoperfusion in hemorrhagic shock. Using cerebral perfusion MIPS is feasible for pre-hospital hemorrhagic shock detection.

备注/Memo

备注/Memo:
 【收稿日期】2018-02-15
【基金项目】国家自然科学基金（81401487）；重庆市社会民生科技创新专项（cstc2016shmszx130082）；重庆市脑科学协同创新中心经费
【作者简介】潘文才，硕士，助理工程师，主要研究方向：失血性休克院前检测和脑血流灌注磁感应相移检测，E-mail: panwencai2010@foxmail.com
【通信作者】赵鹏，博士，高级工程师，主要从事战创伤休克院前急救智能仪器和大型医疗设备质量控制等研究，E-mail: zhaop9@gmail.com
更新日期/Last Update: 2018-06-22