[1]佟颖,尹勇,程品晶,等. 形变配准技术在心脏剂量评估中的应用[J].中国医学物理学杂志,2018,35(5):503-508.[doi:DOI:10.3969/j.issn.1005-202X.2018.05.002]
　TONG Ying,YIN Yong,CHENG Pinjing,et al. Application of deformable image registration in the evaluation of radiation dose to the heart[J].Chinese Journal of Medical Physics,2018,35(5):503-508.[doi:DOI:10.3969/j.issn.1005-202X.2018.05.002]
点击复制

 形变配准技术在心脏剂量评估中的应用()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第5期
页码:
503-508
栏目:
医学放射物理
出版日期:
2018-05-22

文章信息/Info

Title:
 Application of deformable image registration in the evaluation of radiation dose to the heart
文章编号:
1005-202X（2018）05-0503-06
作者:
 佟颖1; 2; 尹勇1; 程品晶2; 卢洁1; 刘同海1; 巩贯忠1
 1.山东大学附属山东省肿瘤医院放射物理技术科， 山东 济南 250117； 2.南华大学核科学技术学院， 湖南 衡阳 421001
Author(s):
 TONG Ying1; 2;  YIN Yong1;  CHENG Pinjing2;  LU Jie1;  LIU Tonghai1;  GONG Guanzhong1
 1. Department of Radiation Physics, Shandong Cancer Hospital Affiliated to Shandong University, Ji’nan 250117, China; 2. School of Nuclear Science and Technology, University of South China, Hengyang 421001, China
关键词:
 ; 形变配准; 剂量; 心脏; 左心室肌
Keywords:
 ; deformable image registration;  radiotherapy dosage;  heart;  left ventricular myocardium
分类号:
R734.2；R815
DOI:
DOI:10.3969/j.issn.1005-202X.2018.05.002
文献标志码:
A
摘要:
 目的：研究基于形变配准技术评估心脏及左心室肌剂量-体积指标的可行性。 方法：回顾性分析21例患者屏气下心电门控四维CT（4DCT），在4DCT的20个时相（0%、5%......95%）上分别勾画心脏、左心室肌。使用商用软件MIM Maestro（MIM）中的基于密度的自由形变算法，将最小体积和以0%时相为参照的最小相似性指数（DSC）时相的心脏、左心室肌分别形变到最大体积和DSC时相上，并参照其形变场对剂量进行相应的形变。分析形变前后心脏及左心室肌相对于最大体积/DSC时相的体积、平均剂量（Dmean）、V20、V30及V40等参数的变化。 结果：将最小体积时相的心脏形变到最大体积时相，形变前后的体积与最大体积的差由（13.87±2.84）%减小到（1.72±1.45）%。将最小DSC时相的心脏形变到最大DSC时相，形变前后的心脏与最大DSC时相相比，其DSC由0.899±0.014增加到0.950±0.009。形变后心脏的Dmean、V20、V30及V40与最大体积/最大DSC时相相比差异均具有统计学意义（P<0.05）。将最小体积时相的左心室肌形变到最大体积时相，形变前后的体积与最大体积时相的差由（18.77±6.64）%仅减小到（17.38±7.89）%，且形变前后的体积与最大体积间的差异均具有统计学意义（P<0.05）。将最小DSC时相的左心室肌形变到最大DSC时相，形变后的左心室肌与最大DSC时相相比，其DSC仅达到0.773±0.052，而形变前后的Dmean、V20、V30及V40等参数与最大DSC时相相比差异均具有统计学意义（P<0.05）。 结论：心脏的剂量-体积指标变化与其体积及形态变化之间没有线性关系，且由于过度形变的存在，有必要对心脏进行局部个体化的形变配准。而左心室肌体积和形态变化的不一致性可能是导致其剂量-体积评估不确定性的主要因素，因此应考虑引入多维参数的形变配准算法。
Abstract:
Objective To discuss the feasibility of applying deformable image registration for assessing dose-volume parameters and the dosimetry parameters of the heart and the left ventricular myocardium (LVM). Methods The electrocardiogram-gate four-dimensional CT images of 21 patients were analyzed retrospectively. The heart and LVM were delineated on 20 phases of 4DCT images (0%, 5%, [?], 95%). With the use of intensity-based free-form deformable registration algorithm of MIM Maestro, the heart and LVM in minimum volume and minimum dice similarity coefficient (DSC) phase (refer to 0% phase) were deformed to maximum volume and maximum DSC phase. Moreover, the dose was also deformed according to the deformation vector. The variations in the volume, mean dose (Dmean), V20, V30 and V40 of heart and LVM before and after deformation registration were compared. Results The variation rate of heart volume before and after the heart in minimum volume was deformed to maximum volume was reduced from (13.87±2.84)% to (1.72±1.45)% compared to maximum volume. The heart in minimum DSC phase were deformed to maximum DSC phase, and the DSC before and after deformation registration were increased from 0.899±0.014 to 0.950±0.009 compared to maximum DSC phase. Statistical differences were found in the Dmean, V20, V30 and V40 of heart between the maximum volume/maximum DSC phase and the deformation phase (P<0.05). The variation rate of volume before and after LVM in minimum volume phase was deformed to maximum volume phase was reduced from (18.77±6.64)% to (17.38±7.89)% compared to maximum volume, and the volume before and after deformation registration were statistically significant compared to maximum volume (P<0.05). The DSC after LVM in minimum DSC phase was deformed to maximum DSC phase was 0.773±0.052 compared with maximum DSC phase. The Dmean, V20, V30 and V40 of LVM before and after deformation registration were statistically significant compared with maximum DSC phase (P<0.05). Conclusion The variation in dose-volume parameters doesn’t have a linear relationship with the variation in volume and morphology for the heart. The local individualized registration should be considered in cardiac deformation due to the excessive deformation. However, the inconsistency of the volumetric variation and the morphological variation of LVM may be a major factor which leads to the uncertainty in dose-volume evaluation, and therefore the deformation algorithm must be designed with the introduction of multidimensional parameters.

相似文献/References:

[1]王遥,霍万里,熊壮,等.TACE手术中不同站姿下铅眼镜和铅面罩对医生眼晶状体防护效果的蒙特卡洛模拟比较[J].中国医学物理学杂志,2016,33(6):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
　[J].Chinese Journal of Medical Physics,2016,33(5):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
[2]张新,谷晓芳,王培臣,等.轻离子束治疗设备注册检验关键技术问题[J].中国医学物理学杂志,2016,33(6):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
　[J].Chinese Journal of Medical Physics,2016,33(5):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
[3]江芬芬,王培,康盛伟,等. 热释光剂量片测量肺部肿瘤放疗剂量的方法[J].中国医学物理学杂志,2016,33(6):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
　[J].Chinese Journal of Medical Physics,2016,33(5):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
[4]刘洪源,彭威,杨锐,等. 锥形束CT离线校正肺癌摆位误差[J].中国医学物理学杂志,2016,33(6):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
　[J].Chinese Journal of Medical Physics,2016,33(5):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
[5]赵彪,潘香,杨毅,等. 右乳癌保乳术后瘤床同步X线和后程电子线补量调强放疗剂量学比较[J].中国医学物理学杂志,2016,33(6):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
　[J].Chinese Journal of Medical Physics,2016,33(5):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
[6]邓南,钱建庭,刁现芬,等. 基于宽带检测放疗X-光光声效应仿体实验[J].中国医学物理学杂志,2016,33(9):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
　[J].Chinese Journal of Medical Physics,2016,33(5):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
[7]张先稳,李军,张西志,等. 宫颈癌术后5野调强放疗4个变量组合的最佳治疗模式的剂量学[J].中国医学物理学杂志,2016,33(9):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
　[J].Chinese Journal of Medical Physics,2016,33(5):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
[8]胡健,李承军,徐利明,等. 床面倾斜对剂量验证通过率的影响[J].中国医学物理学杂志,2016,33(9):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
　[J].Chinese Journal of Medical Physics,2016,33(5):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
[9]陈亚正,肖明勇,孙春堂,等. 准直器角度对宫颈癌术后VMAT计划的影响[J].中国医学物理学杂志,2016,33(9):885.[doi:10.3969/j.issn.1005-202X.2016.09.004]
　[J].Chinese Journal of Medical Physics,2016,33(5):885.[doi:10.3969/j.issn.1005-202X.2016.09.004]
[10]李毅,唐丰文,张晓智. 基于四维CT和锥形束CT确定非小细胞肺癌放疗靶区外放边界[J].中国医学物理学杂志,2016,33(9):892.[doi:10.3969/j.issn.1005-202X.2016.09.005]
　[J].Chinese Journal of Medical Physics,2016,33(5):892.[doi:10.3969/j.issn.1005-202X.2016.09.005]
[11]胡晓伟,孙新臣,李金凯,等. 自动勾画轮廓软件在头颈部锥形束CT中的应用[J].中国医学物理学杂志,2019,36(3):254.[doi:DOI:10.3969/j.issn.1005-202X.2019.03.002]
　HU Xiaowei,SUN Xinchen,LI Jinkai,et al. Application of automatic segmentation software in head and neck cone beam CT[J].Chinese Journal of Medical Physics,2019,36(5):254.[doi:DOI:10.3969/j.issn.1005-202X.2019.03.002]
[12]周琼,李永武,王奇,等. 基于形变配准和伪CT的鼻咽癌自适应放疗剂量评估[J].中国医学物理学杂志,2019,36(8):892.[doi:DOI:10.3969/j.issn.1005-202X.2019.08.006]
　ZHOU Qiong,LI Yongwu,WANG Qi,et al. Dosimetric evaluation of adaptive radiotherapy for nasopharyngeal carcinoma based on deformable registration and synthetic CT[J].Chinese Journal of Medical Physics,2019,36(5):892.[doi:DOI:10.3969/j.issn.1005-202X.2019.08.006]
[13]张祥斌,李光俊,张英杰,等. 基于形变配准算法评估前列腺癌分次间剂量的可行性研究[J].中国医学物理学杂志,2019,36(9):995.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.001]
　ZHANG Xiangbin,LI Guangjun,ZHANG Yingjie,et al. Feasibility of deformable image registration algorithm for interfractional dose calculation in radiotherapy for prostate cancer[J].Chinese Journal of Medical Physics,2019,36(5):995.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.001]

备注/Memo

备注/Memo:
 【收稿日期】2018-02-25
【基金项目】国家自然科学基金（81301936）
【作者简介】佟颖，在读研究生，研究方向：放射物理，E-mail: tongying9208@163.com
【通信作者】巩贯忠，硕士，主管技师，研究方向：放射物理，E-mail:gongguanzhong@yeah.net
更新日期/Last Update: 2018-05-22