[1]魏统辉,刘新凤,崔栋,等. 2型糖尿病患者大脑灰质密度改变及其与认知受损的相关性研究[J].中国医学物理学杂志,2018,35(3):364-368.[doi:DOI:10.3969/j.issn.1005-202X.2018.03.021]
　WEI Tonghui,LIU Xinfeng,CUI Dong,et al. Gray matter density alteration and its correlation with cognitive impairment in patients with type 2 diabetes mellitus[J].Chinese Journal of Medical Physics,2018,35(3):364-368.[doi:DOI:10.3969/j.issn.1005-202X.2018.03.021]
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 2型糖尿病患者大脑灰质密度改变及其与认知受损的相关性研究
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第3期
页码:
364-368
栏目:
脑科学与神经物理
出版日期:
2018-03-20

文章信息/Info

Title:
 Gray matter density alteration and its correlation with cognitive impairment in patients with type 2 diabetes mellitus
文章编号:
1005-202X（2018）03-0364-05
作者:
 魏统辉1; 刘新凤2; 崔栋1; 薛雅卓3; 郭艳成3; 卢爱霞3; 曹卫芳1; 郭永新1; 焦青1
 1.泰山医学院放射学院， 山东 泰安 271016； 2.山东省泰山疗养院， 山东 泰安 271000； 3.泰山医学院护理学院， 山东 泰安 271016
Author(s):
 WEI Tonghui1;  LIU Xinfeng2;  CUI Dong1;  XUE Yazhuo3;  GUO Yancheng3;  LU Aixia3;  CAO Weifang1;  GUO Yongxin1;  JIAO Qing1
 1. School of Radiology, Taishan Medical University, Tai’an 271016, China; 2. Taishan Sanatorium of Shandong Province, Tai’an 271000, China; 3. School of Nursing, Taishan Medical University, Tai’an 271016, China
关键词:
2型糖尿病; 基于体素的形态学分析; 灰质密度; 认知功能受损
Keywords:
 ; type 2 diabetes mellitus;  voxel-based morphology;  gray matter density;  cognitive impairment
分类号:
R445.2；R587.1
DOI:
DOI:10.3969/j.issn.1005-202X.2018.03.021
文献标志码:
A
摘要:
 目的：利用磁共振成像技术结合基于体素的形态学分析方法，探讨2型糖尿病（T2DM）患者大脑灰质密度改变与糖尿病临床指标及认知功能受损之间的关系。方法：采集31名T2DM患者及32名正常人的大脑磁共振结构像，计算全脑体素的灰质密度，提取存在显著差异脑区的灰质密度与临床指标及认知测试结果进行相关性分析。结果：体素的形态学结果显示，与正常对照组相比，T2DM患者右侧小脑、左侧颞中回、左侧枕中回的灰质密度明显降低（P<0.001）。右侧小脑及左侧颞中回的灰质密度分别与简易精神状态检查量表评分呈显著正相关。结论：T2DM患者在小脑、颞叶和枕叶会出现灰质密度降低，且这些脑区的灰质密度降低与患者认知受损有关。
Abstract:
 Objectives To investigate the alteration of gray matter density (GMD) and its correlation with clinical indexes and cognitive impairment in patients with type 2 diabetes mellitus (T2DM) by the analysis method combining magnetic resonance imaging with voxel-based morphology. Methods The magnetic resonance images of 31 patients with T2DM and 32 healthy controls were collected, and GMD was calculated. After the GMD of brain regions showing significant differences were extracted, we analyzed the correlation between extracted GMD with clinical indexes and cognitive test results. Results Voxel-based morphology analysis results showed that GMD in the right cerebellum, the left middle temporal gyrus, and the left middle occipital gyrus was significantly reduced in T2DM patients compared to healthy controls (P<0.001). GMD in the right cerebellum and the left middle temporal gyrus was positively correlated with scores of mini-mental state examination. Conclusion T2DM patients develop structural atrophy in the cerebellum, the temporal lobe and the occipital lobe, and the GMD of these brain regions is related to the cognitive impairment in T2DM patients.

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备注/Memo

备注/Memo:
 【收稿日期】2017-09-27
【基金项目】国家自然科学基金（81371531)；山东省高校科技计划项目（J14LK55）；山东省医药卫生科技发展计划项目（2016WS0603, 2016WS0613）；泰安市科技发展计划项目（2015NS2073, 2015NS2113）
【作者简介】魏统辉，研究方向：医学影像技术，E-mail: 1663422500@qq.com
【通信作者】焦青，博士，教授，研究方向：生物医学信号处理、磁共振成像技术，E-mail: bingbao17@163.com
更新日期/Last Update: 2018-03-21