[1]苏欢繁,全红,梁志文,等.鼻咽癌放疗中3种调强技术对摆位误差的敏感性[J].中国医学物理学杂志,2017,34(11):1102-1105.[doi:DOI:10.3969/j.issn.1005-202X.2017.11.005]
　SU Huanfan,QUAN Hong,LIANG Zhiwen,et al. Sensitivity of 3 kinds of intensity-modulated radiotherapy techniques to setup errors in radiotherapy for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2017,34(11):1102-1105.[doi:DOI:10.3969/j.issn.1005-202X.2017.11.005]
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鼻咽癌放疗中3种调强技术对摆位误差的敏感性()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
34卷
期数:
2017年第11期
页码:
1102-1105
栏目:
医学放射物理
出版日期:
2017-11-20

文章信息/Info

Title:
 Sensitivity of 3 kinds of intensity-modulated radiotherapy techniques to setup errors in radiotherapy for nasopharyngeal carcinoma
文章编号:
1005-202X（2017）11-1102-04
作者:
 苏欢繁1; 全红1; 梁志文2; 张俊3; 明淑凤4
 1.武汉大学物理科学与技术学院， 湖北 武汉 430072； 2.武汉协和医院肿瘤中心， 湖北 武汉 430023； 3.武汉大学中南医院放疗科， 湖北 武汉 430071； 4.蕲春县人民医院肿瘤科， 湖北 黄冈 435300
Author(s):
 SU Huanfan1;  QUAN Hong1;  LIANG Zhiwen2;  ZHANG Jun3;  MING Shufeng4
 1. School of Physics and Technology, Wuhan University, Wuhan 430072, China; 2. Cancer Center, Wuhan Union Hospital, Wuhan 430023, China; 3. Department of Radiotherapy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; 4. Department of Oncology, Qichun People’s Hospital, Huanggang 435300, China
关键词:
 ; 鼻咽癌; 静态调强; 动态调强; 容积旋转调强; 摆位误差; 敏感性
Keywords:
 ; Keywords: nasopharyngeal carcinoma;  static intensity-modulated radiotherapy;  dynamic intensity-modulated radiotherapy;  volumetric-modulated arc radiotherapy;  setup error;  sensitivity
分类号:
R739.6；R815.6
DOI:
DOI:10.3969/j.issn.1005-202X.2017.11.005
文献标志码:
A
摘要:
 【摘 要】 目的：研究治疗鼻咽癌的3种调强技术［静态调强（S-IMRT）、动态调强（D-IMRT）、容积旋转调强（VMAT）］对摆位误差的敏感性。 方法：选择7例鼻咽癌患者，每例患者采用3种调强技术分别设计9野S-IMRT计划、9野D-IMRT计划、双弧VMAT计划，每种计划的优化目标函数相同。然后分别做ArcCheck验证计划，将ArcCheck的等中心点在三维（X、Y、Z）方向分别平移1、2、3、4、5 mm来模拟摆位误差，并重新计算剂量分布。采用SunNuclear Patient QA分析软件将平移后获得的剂量分布与等中心点的剂量分布进行比较，基于[γ]分析方法（3 mm/3%）获得在不同摆位误差下3种调强技术的绝对剂量通过率[（γ33）]，采用单因素方差分析方法比较X（左右）、Y（前后）、Z（腹背）方向的[γ33]，得出不同调强技术对摆位误差敏感性的差异。 结果：在X、Y方向，VMAT的[γ33]显著高于S-IMRT与D-IMRT，在Z方向，VMAT的[γ33]显著低于S-IMRT与D-IMRT；S-IMRT与D-IMRT在三维方向的[γ33]无显著差异。 结论：鼻咽癌的S-IMRT和D-IMRT对摆位误差敏感性无统计学差异，VMAT对Z方向摆位误差相对更敏感，在X、Y方向相对不敏感。
Abstract:
 Abstract: Objective To compare the sensitivity of different radiotherapy techniques to the setup errors in the radiotherapy for nasopharyngeal carcinoma (NPC), including static intensity-modulated radiotherapy (S-IMRT), dynamic intensity-modulated radiotherapy (D-IMRT), volumetric-modulated arc radiotherapy (VMAT). Methods Seven NPC patients were selected, and for each patient, 3 plans with consistent optimized objective function were designed, including 9-field S-IMRT, 9-field D-IMRT, and dual-arc VMAT. After the verification plans were generated based on ArcCheck, the isocenter of ArcCheck was moved 1, 2, 3, 4, 5 mm in three-dimensional directions (X, Y, Z) for simulating the setup errors, and the dose distributions in those plans were re-calculated. SunNuclear patient QA software was used to compare re-calculated dose distributions with the dose distribution of isocenters. The absolute dose passing rate ([γ33]) of different radiotherapy plans with different setup errors were acquired based on gamma analysis (3 mm/3%), and the [γ33] in X (lateral), Y (longitudinal), Z (vertical) directions was compared by one-way ANOVA to obtain the sensitivity of different radiotherapy techniques to setup errors in radiotherapy for NPC. Results In X and Y directions, [γ33 ]of VMAT was significantly higher than that of S-IMRT and D-IMRT, while in Z direction, [γ33] of VMAT was obviously lower than that of S-IMRT and D-IMRT. No statistical differences between S-IMRT and D-IMRT were observed in[γ33] in three-dimensional directions. Conclusion For NPC, S-IMRT and D-IMRT show a similar sensitivity to setup errors, but VMAT was more sensitive in Z direction, less sensitive in X and Y directions as comparison with S-IMRT and D-IMRT.

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备注/Memo

备注/Memo:
 【收稿日期】2017-06-29
【基金项目】医科达-武汉大学医学物理教学科研基金
【作者简介】苏欢繁，硕士在读，研究方向：医用放射治疗技术，E-mail: 1604237717@qq.com
【通信作者】全红，副教授，博士生导师，研究方向：医学影像与放射治疗及纳米技术在肿瘤放化疗中的应用，E-mail: csp6606@sina.com
更新日期/Last Update: 2017-11-23