[1]马长升,黄付静,马长东,等. 评估靶区与危及器官重叠体积对宫颈癌经验引导调强计划自动优化的影响[J].中国医学物理学杂志,2017,34(12):1206-1210.[doi:DOI:10.3969/j.issn.1005-202X.2017.12.004]
　MA Changsheng,HUANG Fujing,MA Changdong,et al. Effect of the overlapping volume of target area and organs-at-risk on the automatic optimization of knowledge-based intensity-modulated radiotherapy plan for cervical cancer[J].Chinese Journal of Medical Physics,2017,34(12):1206-1210.[doi:DOI:10.3969/j.issn.1005-202X.2017.12.004]
点击复制

 评估靶区与危及器官重叠体积对宫颈癌经验引导调强计划自动优化的影响()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
34卷
期数:
2017年第12期
页码:
1206-1210
栏目:
医学放射物理
出版日期:
2017-12-20

文章信息/Info

Title:
 Effect of the overlapping volume of target area and organs-at-risk on the automatic optimization of knowledge-based intensity-modulated radiotherapy plan for cervical cancer
文章编号:
1005-202X（2017）12-1206-05
作者:
 马长升1; 黄付静1; 马长东2; 罗居东1
 1.山东大学附属山东省肿瘤医院放疗科/山东省医学科学院， 山东 济南 250117； 2.山东大学齐鲁医院放疗科， 山东 济南 250012
Author(s):
 MA Changsheng1;  HUANG Fujing1;  MA Changdong2;  LUO Judong1
 1. Department of Radiation Therapy, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Ji’nan 250117, China; 2. Department of Radiation Therapy, Qilu Hospital of Shandong University, Ji’nan 250012, China
关键词:
 ; 【关键词】宫颈癌; 经验引导调强计划; 传统调强计划; 放射治疗剂量; 靶区; 危及器官
Keywords:
 ; Keywords: cervical cancer;  knowledge-based intensity-modulated radiotherapy plan;  conventional intensity-modulated radiotherapy plan;  radiotherapy dosage;  target area;  organs at risk
分类号:
R730.55；R815
DOI:
DOI:10.3969/j.issn.1005-202X.2017.12.004
文献标志码:
A
摘要:
 【摘 要】 目的：通过比较20例宫颈癌术后患者（计划靶区部分与膀胱、直肠重叠）经验引导调强计划（K-IMRT）和传统调强计划（C-IMRT）的剂量学差异，探讨宫颈癌K-IMRT自动优化的可行性。 方法：选取接受调强放射治疗的110例宫颈癌患者，100例患者作为模型组进行自动优化模型的建立，模型组外10例靶区与危及器官有重叠体积患者作为试验组E1（开环验证），模型组内10例靶区与危及器官有重叠体积患者作为实验组E2（闭环验证）。E1、E2组利用自动优化模型生成K-IMRT计划，分别比较两组计划与传统优化计划的剂量学差异。 结果：两组靶区剂量参数相比，E1组各项靶区剂量参数及E2组最小剂量、HI差异均无统计学意义（P>0.05）；E2组K-IMRT计划的最大剂量、CI明显好于C-IMRT计划，差异有统计学意义（P<0.05）。危及器官各参数相比，E1组直肠V20，左右股骨头V15、V20、V25；E2组膀胱V25、V30、V35、D50，直肠V25、V30，左右股骨头V15、V20、V25的K-IMRT计划较C-IMRT计划明显减少，差异有统计学意义（P<0.05）。MU及计划优化时间，K-IMRT计划较C-IMRT计划明显减少。 结论：相对于宫颈癌靶区与危及器官相重叠的患者，K-IMRT计划自动优化是可行的。
Abstract:
 Abstract: Objective To evaluate the feasibility of the automatic optimization of knowledge-based intensity-modulated radiotherapy (K-IMRT) plan for cervical cancer by comparing the dosimetric differences between K-IMRT plan and conventional intensity-modulated radiotherapy (C-IMRT) plan for 20 patients receiving radiotherapy for cervical cancer (part of target area overlaps with the bladder and the rectum). Methods Among the 110 selected cervical cancer patient undergoing radiotherapy, 100 patients served as model group for the establishment of automatic optimization model, and the another 10 cases with overlapping volume of target area and organs-at-risk (OAR) were taken as experimental group E1 (open-loop verification). In model group, 10 patients with overlapping volume of target area and OAR were selected as experimental group E2 (closed-loop verification). In both E1 and E2 groups, the automatic optimization model was used to generate K-IMRT plans which were then compared with C-IMRT plans. Results The target dose parameters in group E1 and the minimum dose and homogeneity index in group E2 didn’t showed any significant differences between C-IMRT plans and K-IMRT plans (P>0.05). In group E2, the maximum dose and conformity index of K-IMRT plans were significantly better than those of C-IMRT plans, with statistical differences (P<0.05). The comparison of OAR parameters showed that compared with C-IMRT plans, K-IMRT plans showed markedly lower V20 of the rectal, V15, V20, V25 of the left and right femoral head in group E1, and had significant reductions in the V25, V30, V35, D50 of the bladder, the V25, V30 of the rectum, the V15, V20, V25 of the left and right femoral head in group E2 (P<0.05). Furthermore, K-IMRT plans had a decreased monitor unit and optimization time as comparison with C-IMRT plans. Conclusion The automatic optimization of K-IMRT plan is feasible for cervical cancer patients with overlapping volume of target area and OAR.

相似文献/References:

[1]王遥,霍万里,熊壮,等.TACE手术中不同站姿下铅眼镜和铅面罩对医生眼晶状体防护效果的蒙特卡洛模拟比较[J].中国医学物理学杂志,2016,33(6):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
　[J].Chinese Journal of Medical Physics,2016,33(12):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
[2]张新,谷晓芳,王培臣,等.轻离子束治疗设备注册检验关键技术问题[J].中国医学物理学杂志,2016,33(6):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
　[J].Chinese Journal of Medical Physics,2016,33(12):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
[3]江芬芬,王培,康盛伟,等. 热释光剂量片测量肺部肿瘤放疗剂量的方法[J].中国医学物理学杂志,2016,33(6):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
　[J].Chinese Journal of Medical Physics,2016,33(12):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
[4]刘洪源,彭威,杨锐,等. 锥形束CT离线校正肺癌摆位误差[J].中国医学物理学杂志,2016,33(6):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
　[J].Chinese Journal of Medical Physics,2016,33(12):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
[5]赵彪,潘香,杨毅,等. 右乳癌保乳术后瘤床同步X线和后程电子线补量调强放疗剂量学比较[J].中国医学物理学杂志,2016,33(6):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
　[J].Chinese Journal of Medical Physics,2016,33(12):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
[6]邓南,钱建庭,刁现芬,等. 基于宽带检测放疗X-光光声效应仿体实验[J].中国医学物理学杂志,2016,33(9):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
　[J].Chinese Journal of Medical Physics,2016,33(12):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
[7]张先稳,李军,张西志,等. 宫颈癌术后5野调强放疗4个变量组合的最佳治疗模式的剂量学[J].中国医学物理学杂志,2016,33(9):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
　[J].Chinese Journal of Medical Physics,2016,33(12):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
[8]胡健,李承军,徐利明,等. 床面倾斜对剂量验证通过率的影响[J].中国医学物理学杂志,2016,33(9):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
　[J].Chinese Journal of Medical Physics,2016,33(12):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
[9]陈亚正,肖明勇,孙春堂,等. 准直器角度对宫颈癌术后VMAT计划的影响[J].中国医学物理学杂志,2016,33(9):885.[doi:10.3969/j.issn.1005-202X.2016.09.004]
　[J].Chinese Journal of Medical Physics,2016,33(12):885.[doi:10.3969/j.issn.1005-202X.2016.09.004]
[10]李毅,唐丰文,张晓智. 基于四维CT和锥形束CT确定非小细胞肺癌放疗靶区外放边界[J].中国医学物理学杂志,2016,33(9):892.[doi:10.3969/j.issn.1005-202X.2016.09.005]
　[J].Chinese Journal of Medical Physics,2016,33(12):892.[doi:10.3969/j.issn.1005-202X.2016.09.005]

备注/Memo

备注/Memo:
 【收稿日期】2017-06-25
【基金项目】中国博士后科学基金（2017M610430）；山东省自然科学基金（ZR2016HM41, ZR2017BA024）；山东省医药卫生科技发展计划项目（2016WS0553）
【作者简介】马长升，博士，助理研究员，研究方向：肿瘤放射物理，E-mail: machangsheng_2000@126.com
更新日期/Last Update: 2017-12-20