Abstract

Info

Title:: Construction of warning model for bleak prognosis of acute ischemic stroke treated with intravenous thrombolysis

Author(s):: LIN Zhichao1; PAN Sijin1; XIE Yulong1; HUANG Lian2; 1. Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China 2. Department of Neurology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China

Keywords:: Keywords: acute ischemic stroke intravenous thrombolysis NIHSS DWI-ASPECTS warning model

Abstract:: Abstract: Objective To analyze the adverse prognostic factors for acute ischemic stroke (AIS) treated with intravenous thrombolysis, and construct a warning model to provide a basis for the prevention and treatment of complications. Methods A total of 256 AIS patients were collected and treated with intravenous thrombolysis within 4.5 h after cerebral hemorrhage and underwent DWI examination within 1 h after medication. Three months after treatment, they were divided into poor prognosis group (n=82, MRS score > 2) and good prognosis group (n=174, MRS score ≤ 2). Logistic regression analysis was used to analyze the adverse prognostic factors for constructing the warning model whose predictive efficacy was evaluated with ROC curve. Results Low DWI-ASPECTS and high NIHSS score were both risk factors for poor prognosis (P=0.01). The ROC curve analysis showed that for predicting poor prognosis, the model had sensitivity, specificity, positive and negative rates of 92%, 47%, 45%, 92% in NIHSS score ≥ 5, 79%, 80%, 65%, 89% in DWI-ASPECTS score < 8, and 93%, 73%, 69%, 94% in NIHSS score ≥ 5 and DWI-ASPECTS score < 8, with significant differences (P<0.01). Conclusion High baseline NIHSS score and low baseline DWI-ASPECTS score are the risk factors for poor prognosis in AIS, and the combined construction of a warning model is helpful to prevent and treat complications after intravenous thrombolysis.