Abstract

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Title:: Diagnostic efficacy of MRI DWI combined with 3D-ASL for acute cerebral infarction and its application in hemodynamic evaluation

Author(s):: XIE Jiaji; YANG Fan; GUO Wei; RUAN Peng; Department of Radiology, Wuhan Third Hospital, Wuhan 430000, China

Keywords:: Keywords: acute cerebral infarction magnetic resonance imaging diffusion-weighted imaging arterial spin labeling

Abstract:: Abstract: Objective To investigate the efficacy of magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI) combined with 3D-arterial spin labeling (3D-ASL) in the diagnosis of acute cerebral infarction (ACI) and its application value in hemodynamic assessment. Methods Eighty cases of ACI were analyzed. All patients were examined with 1.5T/3.0T MRI. The DWI and 3D-ASL image findings of patients with cerebral infarction were analyzed, and the diagnostic value of DWI combined with 3D-ASL for cerebral infarction was evaluated. Results Out of 80 ACI patients, 49 patients had diffusion limitation on DWI images, with an average area of (673±319) mm2 and 3D-ASL hypoperfusion was found in 68 patients, with an average hypoperfusion area of (1 953± 803) mm2. Ischemic penumbra existed in 62 patients who had larger areaASL than areaDWI. In patients with diffusion limitation on DWI images, the absolute value of CBF of the left-sided hyperintensity was lower than that of the right-sided (22.34±4.36 vs 40.58±9.01, P<0.001), and the absolute value of CBF of the right-sided hyperintensity was lower than that of the left-sided (19.48±5.67 vs 46.01±11.15, P<0.001). Compared with DWI alone, DWI combined with 3D-ASL had higher sensitivity, specificity, positive predictive value and negative predictive value in the diagnosis of ACI. Conclusion DWI combined with 3D-ASL has significant application value in the evaluation of infarct focus and ischemic penumbra in ACI.