|Table of Contents|

Effects of vascular tortuosities on pseudo-continuous arterial spin labeling and correction effects of flow-driven adiabatic inversion(PDF)

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

Issue:
2021年第9期
Page:
1113-1118
Research Field:
医学影像物理
Publishing date:

Info

Title:
Effects of vascular tortuosities on pseudo-continuous arterial spin labeling and correction effects of flow-driven adiabatic inversion
Author(s):
YUAN Weiwen1 2 JIANG Guihua2 LUO Zebing1
1. the First School of Clinical Medical, Guangdong Medical University, Zhanjiang 524023, China 2. Department of Imaging, Guangdong Second Provincial General Hospital, Guangzhou 510020, China
Keywords:
pseudo-continuous arterial spin label vascular tortuosity flow-driven adiabatic inversion
PACS:
R318;R445.2
DOI:
10.3969/j.issn.1005-202X.2021.09.012
Abstract:
Objective To investigate the effects of vascular tortuosities on the pseudo-continuous artery spin labeling (PCASL) and the correction effects of flow-driven adiabatic inversion used for labeling. Methods All subjects underwent 4 PCASL scans, including 2 default and 2 modified protocols, and the subjects were divided into control group (the labeling plane intersected at straight parts of vessels) and experimental group (the labeling plane intersected at vascular tortuosities) according to the geometric relationships between the labeling plane and vascular tortuosities. The 2 modified protocols increased the labeling plane distance to 95 and 100 mm, respectively, for avoiding vascular tortuosities. The differences in the PCASLmeasurement results in each group were compared and statistically analyzed.Amathematical model of adiabatic inversion was also established to analyze the effects of the technical principles of flow-driven adiabatic inversion on PCASL. Results The measurement results of the second default and the first modified protocol of the two groups were not statistically different from those of the first default protocol (P>0.05). However, the measurement results of the second modified protocol in both groups were statistically different from those of the first default protocol (P<0.05), and experimental group had a more obvious downward trend than control group. Conclusion The robustness, applicability and repeatability of PCASL are dependent on the blood displacement dependence and adiabaticity of flowdriven adiabatic inversion. The effects caused by vascular tortuosities located inside the labeling plane and those passing through the labeling plane multiple times can be corrected by flow-driven adiabatic inversion, thus there is no actual interference with the PCASL measurement results. The vascular tortuosities between the labeling plane and the imaging area may lower the PCASL measurement results due to T1 effect.

References:

Memo

Memo:
-
Last Update: 2021-09-27