Abstract

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Title:: Metabonomic characteristics of blood serum from patients with chronic obstructive pulmonary disease based on nuclear magnetic resonance

Author(s):: HE Zehao1; WANG Guifang2; CHEN Wenxue3; 1. Department of Physics, Fudan University, Shanghai 200433, China 2. Department of Respiration, Huashan Hospital of Fudan University, Shanghai 200040, China 3. Department of Chemistry, Fudan University, Shanghai 200433, China

Keywords:: Keywords: chronic obstructive pulmonary disease nuclear magnetic resonance statistical analysis biomarker

Abstract:: Abstract: Chronic obstructive pulmonary disease (COPD) is mainly diagnosed by lung function test and chest imaging such as MRI and CT, etc. However, the sensitivities and repeatabilities of these diagnostic techniques for COPD diagnosis were unsatisfactory. Herein nuclear magnetic resonance spectroscopy technique is used to analyze the metabonomic differences of serum samples from 50 healthy controls and 42 patients with COPD in order to find the biomarkers for COPD diagnosis at the molecular level, thereby realizing the early screening for COPD in patients. The results showed that there were significant differences between healthy control group and COPD group in the concentrations of some metabolites such as taurine (δ 3.34-3.30), glutamate (δ 2.50-2.26) and lipid (δ 0.90-0.86), and the concentration ratios of taurine and glutamate over glucose, which suggests that the study can provide some reference for the further research on the potential biomarkers for the diagnosis of COPD.