Dosimetric analysis of helical tomotherapy and volumetric modulated arc therapy for locally advanced nasopharyngeal carcinoma and their effects on the incidence of radiation-induced oral mucositis(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2026年第5期
- Page:
- 575-581
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Dosimetric analysis of helical tomotherapy and volumetric modulated arc therapy for locally advanced nasopharyngeal carcinoma and their effects on the incidence of radiation-induced oral mucositis
- Author(s):
- XU Zhuohua; HE Xiantao; WEI Mingjing; LIU Huajiang; ZHANG Yanxian; JIANG Zhou; YANG Hui; LU Ying
- Department of Oncology, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545007, China
- Keywords:
- Keywords: locally advanced nasopharyngeal carcinoma helical tomotherapy volumetric modulated arc therapy dosimetry radiation-induced oral mucositis
- PACS:
- R811.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2026.05.003
- Abstract:
- Abstract: Objective To investigate the dosimetric characteristics of helical tomotherapy (HT) and volumetric modulated arc therapy (VMAT) for locally advanced nasopharyngeal carcinoma (NPC), and compare the incidence of radiation-induced oral mucositis (ROM) between the two techniques. Methods A total of 160 patients with locally advanced NPC admitted between July 2022 and July 2024 were enrolled. According to radiotherapy plans, they were divided into the HT group and the VMAT group, with 80 cases in each group. Dosimetric characteristics, complications, and incidence of severe ROM were analyzed in both groups. Dosimetric indices included dose-volume histogram parameters of the target volume, homogeneity index, conformity index, and radiation doses of organs-at-risk. Results Compared with the VMAT group, the HT group had higher D99% and conformity index for the target volume, as well as lower Dmax and Dmean of the brainstem, spinal cord, lens, parotid gland, and inner ear (all P<0.05). The rank-sum test revealed significant intergroup differences in ROM (P<0.05), whereas no statistically significant differences were observed in parotid gland injury, radiation dermatitis, or gastrointestinal reactions (P>0.05). The HT group had a lower incidence of severe ROM (grade≥3), delayed initial occurrence, and shorter healing time relative to the VMAT group (all P<0.05). Oral cavity V35, V40, V45, and V50 were lower, whereas V20 and V15 were higher in the HT group than in the VMAT group. Patients with ROM ≥ grade 3 exhibited higher oral cavity Dmax, V60, V55, V50, V45, V40, V35, and V30 than those with ROM
Last Update: 2026-05-28