Prognostic value of CT-assessed skeletal muscle mass at the third cervical vertebra in patients with hypopharyngeal squamous cell carcinoma(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2026年第4期
- Page:
- 484-488
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Prognostic value of CT-assessed skeletal muscle mass at the third cervical vertebra in patients with hypopharyngeal squamous cell carcinoma
- Author(s):
- YIN Lirong; LI Yongxin; LI Jiaqi
- Medical?maging Center, the First Hospital of Qinhuangdao, Qinhuangdao 066001, China
- Keywords:
- Keywords: hypopharyngeal squamous cell carcinoma cervical vertebra skeletal muscle mass computed tomography
- PACS:
- R816.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2026.04.010
- Abstract:
- Abstract: Objective To explore the prognostic value of skeletal muscle mass at the third cervical vertebra (C3) assessed by computed tomography (CT) in patients with hypopharyngeal squamous cell carcinoma. Methods A total of 128 patients with hypopharyngeal squamous cell carcinoma were enrolled, and their 2-year survival status was monitored. According to disease progression and survival status during the 2-year follow-up period, the patients were divided into a good prognosis group (n=89) and a poor prognosis group (n=39). At admission, all patients underwent cervical CT examination, with measurements of C3 skeletal muscle area, C3 skeletal muscle density, skeletal muscle index (SMI), and intermuscular adipose tissue (IMAT). Other clinical data included gender, body mass index, age, primary tumor site, presence or absence of lymph node metastasis, and clinical stage. Multivariate Logistic analysis was performed to analyze the factors affecting patient survival. The prognostic value of C3 skeletal muscle area, C3 skeletal muscle density, SMI, and IMAT in patients with hypopharyngeal squamous cell carcinoma was evaluated using ROC curve analysis. Results The proportions of patients with lymph node metastasis and advanced-stage tumor were higher in the poor prognosis group than in the good prognosis group. Compared with the good prognosis group, the poor prognosis group had significantly lower C3 skeletal muscle density ［(35.33±5.32) HU vs (39.21±8.54) HU, t=2.620, P<0.01］, C3 skeletal muscle area ［(32.91±7.12) cm2 vs (36.12±6.25) cm2, t=2.558, P<0.05］, and SMI［(9.51±2.25) cm2/m2 vs (12.66±3.32) cm2/m2, t=5.401, P<0.001］. The IMAT in the poor prognosis group was higher than that in the good prognosis group ［(7.21±0.66) cm2 vs (6.25±0.89) cm2, t=-6.783, P<0.001］. Multivariate Logistic regression analysis identified metastasis, advanced-stage tumor, and high IMAT as risk factors for poor prognosis in patients with hypopharyngeal squamous cell carcinoma, whereas high C3 skeletal muscle density, larger C3 skeletal muscle area, and high SMI were protective factors (P<0.05). ROC curve analysis showed that the AUC values for C3 skeletal muscle density, C3 skeletal muscle area, SMI, and IMAT in predicting the prognosis of patients with hypopharyngeal squamous cell carcinoma were 0.663 (95% CI: 0.569-0.756), 0.632 (95% CI: 0.525-0.740), 0.788 (95% CI: 0.709-0.866), and 0.811 (95% CI: 0.721-0.901), respectively. The combination of the 4 factors resulted in an AUC value of 0.917 (95% CI: 0.874-0.965). Conclusion The CT-assessed C3 skeletal muscle mass shows favorable prognostic value in patients with hypopharyngeal squamous cell carcinoma.
Last Update: 2026-04-29