Abstract

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Title:: Compensatory calculation of radiotherapy interruption based on radiobiological modeling and its clinical application

Author(s):: SU Huanfan1; MA Li2; QUAN Enzhuo2; DAI Zhitao2; 1. Department of Medical Imaging, Jiangxi Medical College, Shangrao 334000, China 2. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518100, China

Keywords:: Keywords: radiobiology radiotherapy interruption compensatory calculation biologically effective dose model

Abstract:: Abstract: Prolonged total treatment time due to radiotherapy interruptions is detrimental to local tumor control. There are multiple causes that contribute to the occurrence of interruption events during radiotherapy, including public holidays, machine breakdown and maintenance, and radiotherapy complications. If treatment interruption events are unavoidable during radiotherapy, compensatory approaches should be taken to minimize the effects of radiotherapy interruptions on tumor control. Herein the study provides a summary on the causes and influence of radiotherapy interruptions, the ideas of interruption compensation, and the biological models of radiotherapy interruption compensation, such as nominal standard dose, cumulative radiation effect, time-dose fractionation factors, biologically effective dose models, etc. Additionally, the compensatory calculation for radiotherapy interruption in nasopharyngeal carcinoma is taken as an example to provide a reference for the quantitative compensation calculation for radiotherapy interruption in clinic.