Analysis and prediction of the correlations between morphological and dosimetric parameters in different locations of esophageal cancer based on multi-to-multi double screening stepwise regression method(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2024年第12期
- Page:
- 1486-1493
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Analysis and prediction of the correlations between morphological and dosimetric parameters in different locations of esophageal cancer based on multi-to-multi double screening stepwise regression method
- Author(s):
- ZHAO Wenjuan1; 2; XU Bichun2; CHEN Di2; ZENG Fubin1; 2; HE Jie1; 2; LAN Linzhen3; ZENG Yusha4; ZHANG Huojun2
- 1. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China 2. Department of Radiation Oncology, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China 3. Department of Radiotherapy, Cancer Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China 4. Department of Radiotherapy, Fujian Provincial Hospital, Fuzhou 350001, China
- Keywords:
- Keywords: esophageal cancer intensity-modulated radiotherapy multi-to-multi double screening stepwise regression method
- PACS:
- R318；R811.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2024.12.005
- Abstract:
- Abstract: Objective To analyze the correlation between morphological and dosimetric parameters in patients with esophageal cancer at different locations using multi-to-multi double screening stepwise regression method, and to make simple predictions. Methods A retrospective analysis was conducted on 105 patients with advanced esophageal cancer who underwent radiotherapy at the First Affiliated Hospital of Fujian Medical University from 2019 to 2021. Morphological parameters of organs-at-risk were collected from CT images, and intensity-modulated radiotherapy plans were developed using Raystation4.7. The prescription doses for PTV-G and PTV-C were 60 Gy/30 F and 54 Gy/30 F, respectively. Multi-to-multi double screening stepwise regression method was employed to analyze the correlation between morphological and dosimetric parameters in esophageal cancer patients, and some preliminary predictions were provided. Results The dosimetric volume parameters of the lungs and heart were correlated with PTV-G volume, PTV-G length, PTV-G cross-sectional area, left and right lung volumes, lung length and total lung volume (P<0.05). For upper thoracic esophageal cancer, dosimetric volume parameters of the lungs and heart were correlated with PTV-G volume, PTV-G length, and right lung volume (P<0.05). For middle thoracic esophageal cancer, dosimetric volume parameters of the lungs, heart, and spinal cord were correlated with PTV-G volume, PTV-G length, PTV-G cross-sectional area, left and right lung volumes, and lung length (P<0.05). For lower thoracic esophageal cancer, dosimetric volume parameters of the lungs, heart, and spinal cord were correlated with PTV-G volume, PTV-G length, right lung volume, and lung length (P<0.05). Conclusion For patients with tumors at different locations, both overall and segmental analyses should be considered to balance therapeutic effect and side effects of radiotherapy, thereby maximizing the benefits for tumor patients.
Last Update: 2024-12-20