Effects of low-frequency rTMS combined with paroxetine on clinical symptoms and social abilities in patients with panic disorder(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2023年第12期
- Page:
- 1554-1557
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Effects of low-frequency rTMS combined with paroxetine on clinical symptoms and social abilities in patients with panic disorder
- Author(s):
- XU Chengyu1; WU Yufeng2; ZHOU Dan3
- 1. Department of Psychiatry, Wuzhou Second Peoples Hospital, Wuzhou 543001, China 2. The Second Department of Infectious Diseases, Guidong Peoples Hospital of Guangxi Zhuang Autonomous Region, Wuzhou 543001, China 3. Department of Neurosurgery, Dongguan Qingxi Hospital, Dongguan 523658, China
- Keywords:
- Keywords: panic disorder low-frequency repetitive transcranial magnetic stimulation paroxetine clinical symptom social ability
- PACS:
- R749.99
- DOI:
- DOI:10.3969/j.issn.1005-202X.2023.12.015
- Abstract:
- Abstract: Objective To explore the effects of the combination of low-frequency repetitive transcranial magnetic stimulation (rTMS) and paroxetine on clinical symptoms and social abilities in patients with panic disorder. Methods A total of 90 patients with panic disorder were randomly divided into observation group (n=45, low-frequency rTMS combined with paroxetine) and control group (n=45, paroxetine alone). All were continuously treated for 6 weeks. The clinical symptoms were evaluated with panic disorder severity scale (PDSS) and Hamilton anxiety scale (HAMA) for assessing the therapeutic effect and the social abilities were evaluated with global assessment function (GAF) and perceived social support scale (PSSS). The occurrence of adverse reactions during treatment was recorded. Results After 4 and 6 weeks of treatment, compared with control group, observation group had lower PDSS score and HAMA score (Ftime=566.213, 533.124, P<0.05 Fbetween-group=13.211, 4.466, P<0.05), and higher GAF score and PSSS score (Ftime=486.312, 497.112, P<0.05 Fbetween-group=62.601, 123.510, P<0.05). After 4 and 6 weeks of treatment, the response rates in observation group were 80.00% and 91.11%, higher than 60.00% and 71.11% in control group (P<0.05). There was no significant difference in total incidence of adverse reactions between observation group and control group (22.22% vs 17.78%, P>0.05). Conclusion The combination of low-frequency rTMS and paroxetine can effectively relieve anxiety, improve clinical symptoms, therapeutic effect and social abilities in patients with panic disorder, with certain safety and bringing more benefits as compared with paroxetine alone.
Last Update: 2023-12-27