Comparison of clinical effects and dosimetric differences of different radiotherapy regimens in the treatment of cervical cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2022年第6期
- Page:
- 671-675
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Comparison of clinical effects and dosimetric differences of different radiotherapy regimens in the treatment of cervical cancer
- Author(s):
- YU Juan1; HOU Yutao2
- 1. Department of Oncology, Zhangjiajie Peoples Hospital, Zhangjiajie 427000, China 2. Department of General Medicine, Affiliated Hospital of Xiangnan University, Chenzhou 423000, China
- Keywords:
- Keywords: cervical cancer radiotherapy delivered using four-field-box-technique intensity-modulated radiotherapy dosimetry
- PACS:
- R815
- DOI:
- DOI:10.3969/j.issn.1005-202X.2022.06.003
- Abstract:
- Abstract: Objective To compare the clinical effects and dosimetric differences of different radiotherapy regimens in the treatment of cervical cancer. Methods Ninety-two cervical cancer patients were enrolled as the research subjects, and divided into control group (n=45) and observation group (n=47) according to their radiotherapy regimens. Patients in control group were treated with radiotherapy delivered using four-field-box-technique, while those in observation group were treated with intensity-modulated radiotherapy (IMRT). The long-term therapeutic effects, differences in dose to target areas and organs-at-risk, and incidences of adverse reactions to radiotherapy were compared between two groups. Results The 3-year overall survival rate and local control rate in observation group were 91.48% and 95.74%, which were slightly higher than those in control group (88.88% and 91.11%), without statistical differences (P>0.05). The maximum dose, mean dose and conformity index of planning target area in observation group were higher than those in control group, while the minimum dose and homogeneity index of planning target area were lower than those in control group (P<0.05). The incidences of gastrointestinal reaction, bone marrow suppression, abdominal pain/diarrhea, frequent micturition/dysuria, skindamage, edema of lower limbs, late rectal reaction and late bladder reaction in observation group were lower than those in control group (P<0.05). Conclusion IMRT for corvical cancer is advantageous in the dose distributions of target area and organs-at-risk, and moreover, it can reduce the incidences of adverse reactions to radiotherapy.
Last Update: 2022-06-27