Abstract

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Title:: A multicenter study on eradication of oral Helicobacter pylori in children to prevent gastric Helicobacter pylori infection

Author(s):: HUANG Chao1; PENG Weiqiang2; WU Haitao3; ?HENG Shuiying2; ?HEN Jiaojiao4; ZHAO Qingbo5; ZHONG Haibin6; ?MA Jian7; ZHAO Li4; 1. Department of Spleen and Stomach, Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University (Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine), Shenzhen 518104, China 2. General Department, Dongguan Dental Hospital, Dongguan 523000, China 3. Department of Dental Implantation, Dongguan Dental Hospital, Dongguan 523000, China 4. Department of Periodontology, Dongguan Dental Hospital, Dongguan 523000, China 5. Guangdong Etron Technology Development Co., Ltd, Guangzhou 511442, China 6. Internal Medicine Area II, Wuhua Hospital of Traditional Chinese Medicine, Meizhou 514400, China 7. Peoples Hospital of Huangnan Tibetan Autonomous Prefecture of Qinghai Province, Huangnan 811300, China

Keywords:: Keywords: oral cavity stomach children Helicobacter pylori infection

Abstract:: Abstract: Objective To investigate the possibility of preventing gastric Helicobacter pylori (Hp) infection by eradicating oral Hp in children. Methods A multicenter prospective randomized study was conducted on 427 kindergarten children who had Hp positive expression in oral cavity but Hp negative expression in stomach. According to the treatment, the children were randomly divided into two groups, namely wuyoumei toothpaste group and ordinary toothpaste group. After the completion of treatment course, oral Hp was detected again, and according to the detection results, the children were grouped into oral Hp positive expression group and negative expression group. One year later, C13 breath test was performed to analyze the gastric Hp infection in two groups. In the study, oral Hp was detected by nested PCR with high specificity and high sensitivity. Results One-year follow-up showed that the gastric Hp infection rate was 0.51% in oral Hp negative expression group and 6.51% in oral Hp positive expression group, with significant differences between two groups (P<0.01). Conclusion Eradication of oral Hp in children can reduce the incidence of gastric Hp infection.