Abstract

Info

Title:: Numerical simulation of abnormal discharge of nuclei and FPGA implementation

Author(s):: WANG Chao; LU Mai; Key Laboratory of Optoelectronic Technology and Intelligent Control, Ministry of Education, Lanzhou Jiaotong University, Lanzhou 730070, China

Keywords:: Keywords: basal ganglia network of nuclei FPGA Izhkevich model numerical simulation

Abstract:: Abstract: Objective To realize the numerical simulation of abnormal discharge of nuclei and its hardware implementation. Methods Izhikevich model was used to simulate single neuron discharge, and neurons were connected via chemical synapses to build the network of nuclei, and finally, the discharge of nuclei was realized on FPGA. The root mean squared error was used to compare the results of Izhikevich modeling by Simulink versus DSP Builder, and the discharge characteristics of different nuclei were analyzed. Results The root mean squared error of simulation results between Simulink and DSP Builder was all less than 0.1, which verifies the consistency of the modeling. The calculated reliability index of the thalamic cortex was 0.3, less than 0.6, which proved that a discharge state of Parkinsons disease could by simulated by the established network of nuclei. Conclusion Simulating the abnormal discharge of nuclei is of significance for replacing the experiments in vivo, exploring the treatment of neurological diseases and studying brain-machine interface.