Abstract

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Title:: Magnetic resonance imaging study of hippocampal functional connectivity in type 2 diabetes patients

Author(s):: WANG Chuanna1; LÜ Shuang1; GUO Gaode1; XUE Yazhuo2; CUI Dong1; CAO Weifang1; LIU Xinfeng3; GUO Yongxin1; JIAO Qing1; 1. School of Radiology, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, China 2. School of Nursing, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, China 3. Taishan Sanatorium of Shandong Province, Taian 271000, China

Keywords:: type 2 diabetes hippocampus brain functional connectivity functional magnetic resonance imaging

Abstract:: Objective To investigate the abnormal resting-state hippocampal functional connectivity (FC) in patients with type 2 diabetes (T2D) by functional magnetic resonance imaging technology. Methods The brain functional magnetic resonance imaging signals of 27 T2DM patients and 32 healthy controls were collected. Four sub-regions of the hippocampus were chosen as seeds for FC calculation. The correlation between clinical indices and the FC between the hippocampus and other brain regions was investigated. Results Compared with healthy controls, T2D patients showed reduced FC between the right anterior hippocampus and fusiform gyrusm, middle occipital gyrus, and between the right posterior hippocampus and calcarine. Moreover, there was increased FC in T2D patients between the left anterior hippocampus and fusiform gyrus, and between the left posterior hippocampus and lingual gyrus. Conclusion The changes of brain FC in T2D patients may play a role in vision-related cognitive impairments, which provides clues in understanding the function of hippocampus in T2D patients.