Effects of fluid shear stress on human periodontal ligament cells: a review(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第7期
- Page:
- 908-911
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Effects of fluid shear stress on human periodontal ligament cells: a review
- Author(s):
- MA Chenghua; ZHANG Yu; JING Pengju; LI Peiwu
- Emergency Center, Lanzhou University Second Hospital, Lanzhou 730000, China
- Keywords:
- Keywords: fluid shear stress periodontal ligament cell signaling pathway cell proliferation cell differentiation review
- PACS:
- R782.1；R318
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.07.021
- Abstract:
- Abstract: The study aims to clarify the effects of fluid shear stress on periodontal ligament cells and provide a theoretical basis for subsequent related researches. By reviewing the related literatures, it is revealed that fluid shear stress can promote the osteogenic differentiation of periodontal ligament cells via miRNA-132/PI3K/mTOR signaling pathway, ERK/p38/JNK MAPK signaling pathway and Wnt/LEF-1 signaling pathway. In addition, fluid shear stress can also regulate the proliferation of periodontal ligament cells, inhibit cell migration, and affect the expression of inflammatory factor COX-2. In the future, the exact proliferation effect of fluid shear stress on periodontal ligament cells and its specific mechanism can be further studied.
Last Update: 2020-07-28