Clinical values of 1.5T magnetic resonance imaging in detection of female breast cancer and its correlation with Her-2(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第12期
- Page:
- 1441-1446
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Clinical values of 1.5T magnetic resonance imaging in detection of female breast cancer and its correlation with Her-2
- Author(s):
- SHI Xubo1; HUANG Guisheng1; SU Huanhuan2; YAN Jianhao2
- 1. Imaging Center, Jieyang Ciyun Hospital, Jieyang 522031, China; 2. Department of Imaging, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
- Keywords:
- ; Keywords: breast cancer; magnetic resonance imaging; human epidermal growth factor receptor-2; maximum linear slope
- PACS:
- R445.2；R737.9
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.12.014
- Abstract:
- Abstract: Objective To investigate the application value of 1.5T magnetic resonance imaging (MRI) in the detection of female breast cancer and analyze its correlation with human epidermal growth factor receptor-2 (Her-2). Methods A total of 60 patients with breast cancer confirmed by surgery and pathology in Jieyang Ciyun Hospital from September 2015 to September 2017 were selected as breast cancer group, while 60 cases of benign breast diseases were selected as benign group. All patients underwent 1.5T MRI examination. The maximum signal intensity (SImax), time to peak (Tpeak), early enhancement rate (EER), and maximum linear slope (Slope) were compared between the two groups. The expression levels of Her-2 mRNA in two groups of lesions were measured. The correlation between MRI parameters and Her-2 mRNA expression level was analyzed. Results The expression levels of EER, Slope and Her-2 mRNA in breast cancer group were higher than those in benign group, but SImax and Tpeak were lower in breast cancer group than in benign group, with statistical differences (P<0.05). The area under the curve of SImax, Tpeak, EER and Slope in predicting breast cancer was 0.841, 0.868, 0.846 and 0.779, respectively. Among them, area under the curve of Tpeak in predicting breast cancer was the largest, and the area under the curve predicted by Slope was the smallest. By Pearson linear correlation analysis, it was found that SImax and Tpeak were negatively correlated with Her-2 mRNA expression (r=0.753, 0.701, all P<0.05), and that EER and Slope were positively correlated with Her-2 mRNA expression (r=0.810, 0.749, all P<0.05). Conclusion With the decrease of Her-2 mRNA expression, SImax and Tpeak increase, while ER and Slope decrease. 1.5T MRI parameters, namely EER, Slope, SImax and Tpeak, have certain values in predicting breast cancer, providing the basis for the diagnosis and treatment of breast cancer.
Last Update: 2018-12-26