Analysis of hemolytic performance of continuous blood pump(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第9期
- Page:
- 1087-1093
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Analysis of hemolytic performance of continuous blood pump
- Author(s):
- ZHANG Jinli1; CHENG Yunzhang1; ZHENG Qiwen2
- 1. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;
2. ForQaly Medical (Shanghai) Company Limited, Shanghai 201138, China
- Keywords:
- continuous blood pump; hemolysis; computational fluid dynamics; hemolysis experiment
- PACS:
- R318.6
- DOI:
- 10.3969/j.issn.1005-202X.2018.09.017
- Abstract:
- Hemolytic performance is one of the main factors affecting the reliability of blood pump. Effective evaluation of
hemolytic performance provides a strong basis for the design and improvement of blood pump. Herein, the commonly used
methods for hemolysis evaluation in the research and development of blood pump were summarized, including hemolysis
estimation and hemolysis experiment. Firstly, the hemolysis estimation was described, including the theoretical numerical
estimation model and the hemolysis analysis based on the computational fluid dynamics technique. After the model prototype
was developed, the hemolysis experiments were introduced, including cardiopulmonary bypass simulation and animal experiment.
Secondly, the advantages and limitations of the two methods were compared, and the comparison results showed that hemolysis
estimation was preferred in the pre-development of blood pump, while hemolysis experiment was suitable for hemolytic evaluation
with model prototype in the middle and later stages. The hemolysis estimation laid the foundation for hemolysis experiment which
verified the results of hemolysis estimation. The hemolysis experiment and numerical estimation were mutual connection and
mutual promotion, but they could not be completely replaced. Different researchers and research institutes should choose the
appropriate evaluation method according to their own conditions. Finally, the problems and the development trends in the
evaluation of blood pump hemolysis were discussed.
Last Update: 2018-09-28