Dosimetric comparison of volumetric modulated arc therapy and intensity-modulated radiotherapy for non-small cell lung cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第4期
- Page:
- 389-393
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Dosimetric comparison of volumetric modulated arc therapy and intensity-modulated radiotherapy for non-small cell lung cancer
- Author(s):
- CAI Juntao; CHEN Fan; WANG Cai; FENG Ruixing; YIN Lin; CHANG Qiaomei; WANG Xiaoli; LIU Zining; LIN Jing
- Department of Radiation Oncology, Affiliated Hospital of Qinghai University, Xining 810001, China
- Keywords:
- ; non-small cell lung cancer; volumetric modulated arc therapy; intensity-modulated radiotherapy; radiotherapic dose
- PACS:
- R811.1；R734.2
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.04.004
- Abstract:
- Objective To compare the dosimetric differences in target areas and organs-at-risk (OAR) between volumetric modulated arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC). Methods Four different kinds of plans, namely 5-field IMRT (5F-IMRT), 7-field IMRT (7F-IMRT), double-arc VMAT (D-VMAT) and partial-arc VMAT (P-VMAT), were designed for 20 NSCLC patients receiving radiotherapy for the first course. The dose distribution in target areas and OAR dose-volume parameters were compared. Results No significant differences were found in the Dmean of planning target areas among the 4 plans (P>0.05). The homogeneity index and conformal index of two VMAT plans were better than those of two IMRT plans (P<0.05). Compared with the other 3 plans, D-VMAT plans had the highest mean lung dose (P<0.05). The V5 and V10 of lungs in P-VMAT plan were slightly better than those in D-VMAT plan (P<0.05), and both of them were higher than those in two IMRT plans (P<0.05). The V20 of lungs in P-VMAT was the optimal among the 4 plans, and the differences between the 4 plans were statistically significant (P<0.05). D-VMAT and P-VMAT plans had similar V30 of lungs (P>0.05), superior to two IMRT plans (P<0.05). The comparison of the V30 of lungs and the V30, V40 of heart between the 4 plans didn’t showed any statistical differences (P>0.05). The Dmax of spinal cord in P-VMAT was the lowest among the 4 plans, and the differences were statistically significant as compared with other plans (P<0.05). Conclusion The target dose distributions in D-VMAT and P-VMAT plans for NSCLC are better than those in IMRT plans, moreover, P-VMAT shows more advantages in OAR sparing. Therefore, P-VMAT is recommended preferentially in radiotherapy for NSCLC, but 7F-IMRT is recommended for cases in which the low dose areas of lung is the main focus, while the target dose distribution is secondarily considered.
Last Update: 2018-04-23