Abstract

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Title:: Analysis of coagulation process based on frequency-domain analysis of thrombelastographic parameters

Author(s):: MOU Qiongyao; ZHOU Qi; LIU Shengxiong; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China

Keywords:: ; thrombelastography; coagulation; frequency-domain analysis; spectrum parameter

Abstract:: Compared with the conventional detection methods, thrombelastography (TEG) allows dynamic observation of the entire process of platelet aggregation, coagulation and fibrinolysis for rapid and accurate evaluation of the overall coagulation function. But the various evaluation parameters of TEG cause much complexity and confusion for the clinicians in making a quick and effective evaluation of the patient’s condition. Herein we use a frequency-domain analysis-based method for studying different types of TEG patterns by assessing TEG parameters in the context of the working principle of TEG. We also explored the frequency-domain characteristics of TEG and proposed a set of frequency-domain evaluation parameters with a reduced number of TEG parameters to facilitate clinical evaluation of the patient’s condition. The experimental results showed that the frequency-domain parameter Fm (the maximum spectrum value) and Δf (band width) were correlated with K time, TMA, α angle and the maximum amplitude. The range of the parameters directly reflects the changes in the coagulation process that have physiological and pathological significance.