Effect of the overlapping volume of target area and organs-at-risk on the automatic optimization of knowledge-based intensity-modulated radiotherapy plan for cervical cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2017年第12期
- Page:
- 1206-1210
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Effect of the overlapping volume of target area and organs-at-risk on the automatic optimization of knowledge-based intensity-modulated radiotherapy plan for cervical cancer
- Author(s):
- MA Changsheng1; HUANG Fujing1; MA Changdong2; LUO Judong1
- 1. Department of Radiation Therapy, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Ji’nan 250117, China; 2. Department of Radiation Therapy, Qilu Hospital of Shandong University, Ji’nan 250012, China
- Keywords:
- ; Keywords: cervical cancer; knowledge-based intensity-modulated radiotherapy plan; conventional intensity-modulated radiotherapy plan; radiotherapy dosage; target area; organs at risk
- PACS:
- R730.55；R815
- DOI:
- DOI:10.3969/j.issn.1005-202X.2017.12.004
- Abstract:
- Abstract: Objective To evaluate the feasibility of the automatic optimization of knowledge-based intensity-modulated radiotherapy (K-IMRT) plan for cervical cancer by comparing the dosimetric differences between K-IMRT plan and conventional intensity-modulated radiotherapy (C-IMRT) plan for 20 patients receiving radiotherapy for cervical cancer (part of target area overlaps with the bladder and the rectum). Methods Among the 110 selected cervical cancer patient undergoing radiotherapy, 100 patients served as model group for the establishment of automatic optimization model, and the another 10 cases with overlapping volume of target area and organs-at-risk (OAR) were taken as experimental group E1 (open-loop verification). In model group, 10 patients with overlapping volume of target area and OAR were selected as experimental group E2 (closed-loop verification). In both E1 and E2 groups, the automatic optimization model was used to generate K-IMRT plans which were then compared with C-IMRT plans. Results The target dose parameters in group E1 and the minimum dose and homogeneity index in group E2 didn’t showed any significant differences between C-IMRT plans and K-IMRT plans (P>0.05). In group E2, the maximum dose and conformity index of K-IMRT plans were significantly better than those of C-IMRT plans, with statistical differences (P<0.05). The comparison of OAR parameters showed that compared with C-IMRT plans, K-IMRT plans showed markedly lower V20 of the rectal, V15, V20, V25 of the left and right femoral head in group E1, and had significant reductions in the V25, V30, V35, D50 of the bladder, the V25, V30 of the rectum, the V15, V20, V25 of the left and right femoral head in group E2 (P<0.05). Furthermore, K-IMRT plans had a decreased monitor unit and optimization time as comparison with C-IMRT plans. Conclusion The automatic optimization of K-IMRT plan is feasible for cervical cancer patients with overlapping volume of target area and OAR.
Last Update: 2017-12-20