Applications of laser speckle contrast imaging in cerebral blood flow research(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2026年第4期
- Page:
- 455-461
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Applications of laser speckle contrast imaging in cerebral blood flow research
- Author(s):
- YANG Dan; LIU Li; LIU Shuangshuang; ZHANG Chengcheng; WANG Liyan; FANG Sanhua
- Core Facilities of School of Medicine, Zhejiang University, Hangzhou 310058, China
- Keywords:
- Keywords: laser speckle contrast imaging cerebral blood flow high spatiotemporal resolution cerebral ischemia brain tumor review
- PACS:
- R318.51； R743
- DOI:
- DOI:10.3969/j.issn.1005-202X.2026.04.005
- Abstract:
- Abstract: Laser speckle contrast imaging, as an emerging optical imaging technology, has become a core tool in cerebral blood flow monitoring owing to its advantages including high spatiotemporal resolution, label-free detection, and simple operation. A systematical review on its basic principles, technical improvements, application progress, and challenges is provided. It briefly describes the core principles of speckle formation and contrast analysis, encompassing classical analytical methods such as spatial laser speckle contrast analysis and temporal laser speckle contrast analysis, with a special focus on key technical breakthroughs in resolution enhancement, quantitative optimization, motion artifact suppression, and optical clearing. Furthermore, the monitoring achievements and clinical translational exploration in scenarios such as normal brain physiology, cerebral ischemia, and brain tumors are comprehensively summarized, and the core challenges including imaging depth extension and quantitative method standardization are analyzed. Based on recent research, technical bottlenecks are further refined. Finally, the development trends including multimodal fusion are prospected, and the corresponding implementation paths are clarified. This review provides comprehensive technical references for researchers in biomedicine and optical engineering, and facilitates the widespread and in-depth application of laser speckle contrast imaging in cerebral blood flow monitoring and related disease research.
Last Update: 2026-04-28