Evaluation of brain perfusion abnormalities in patients with first-episode schizophrenia using arterial spin labeling perfusion imaging(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2026年第4期
- Page:
- 462-466
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Evaluation of brain perfusion abnormalities in patients with first-episode schizophrenia using arterial spin labeling perfusion imaging
- Author(s):
- MOU Junyi? JIANG Guihua? GUO Fei3; MA Cunwen3
- 1. The Second Clinical Medical College, Southern Medical University, Guangzhou 510515, China 2. Department of Radiology, the Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China 3. Department of Radiology, the Peoples Hospital of Wenshan Zhuang and Miao Autonomous Prefecture, Wenshan 663000, China
- Keywords:
- Keywords: first-episode schizophrenia resting-state functional magnetic resonance imaging arterial spin labeling cerebral blood flow perfusion
- PACS:
- R749.3；R816.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2026.04.006
- Abstract:
- Abstract: Objective To systematically evaluate the localization, quantitative characteristics, and distribution patterns of abnormal cerebral perfusion in patients with first-episode schizophrenia using arterial spin labeling perfusion MRI, and clarify the alteration patterns of cerebral blood flow perfusion in the early stage of the disease, thereby providing an objective basis for exploring the pathophysiological mechanisms, early imaging diagnosis, and clinical intervention of first-episode schizophrenia. Methods A total of 76 participants were enrolled, including 38 patients with first-episode schizophrenia and 38 healthy controls, and their ASL perfusion imaging data were acquired. After standardized preprocessing, cerebral blood flow (CBF) values were extracted from the whole brain and regions of interest. Between-group comparisons and correlation analyses were subsequently conducted to evaluate alterations in abnormal connectivity patterns of brain networks. Results Compared with healthy controls, patients with first-episode schizophrenia showed significantly increased CBF in the frontal lobe and significantly decreased CBF in the temporal lobe. Conclusion Patients with first-episode schizophrenia present a pattern of cerebral functional imbalance characterized by hyperactivation in the frontal lobe and hypoactivation in the temporal lobe, and these abnormalities are closely associated with clinical symptoms and cognitive function. Dysfunctional coordination between the prefrontal and temporal lobes emerges in the early stage of the disease, which may constitute the core pathological mechanism underlying the early onset of schizophrenia.
Last Update: 2026-04-28