Comparison of flow field characteristics and hemodynamics between eccentric and concentric coronary stenoses based on fluid-structure interaction(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2026年第7期
- Page:
- 970-979
- Research Field:
- 生物材料与力学
- Publishing date:
Info
- Title:
- Comparison of flow field characteristics and hemodynamics between eccentric and concentric coronary stenoses based on fluid-structure interaction
- Author(s):
- CHEN Aoxue1; WU Meijing1; TANG Hui2; CAO Hang2; LIU Han2; TANG Lu2; ZHAO Yinghong2
- 1. School of Medical Technique, Xuzhou Medical University, Xuzhou 221004, China 2. School of Medical Imaging, Xuzhou Medical University, Xuzhou 221004, China
- Keywords:
- Keywords: coronary artery stenosis fluid-structure interaction eccentric stenosis hemodynamics
- PACS:
- R318
- DOI:
- DOI:10.3969/j.issn.1005-202X.2026.07.019
- Abstract:
- Abstract: Objective To quantitatively analyze the differential effects of eccentric versus concentric stenoses at different anatomical sites with various severities on hemodynamics and vescular wall stresses using fluid-structure interaction (FSI). Methods Based on patient-specific coronary computed tomography angiography (CCTA) data, a series of coronary artery models featuring distinct geometric configurations were reconstructed. Two-way FSI coupling calculations were executed using patient-specific pulsatile pressure profiles as inlet conditions and a three-element Windkessel (RCR) model as outlet boundary conditions. A comprehensive multi-parametric analysis was conducted to evaluate flow patterns, time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), and structural von Mises stress (VMS) within the vessel wall. Results Eccentric geometric features significantly reshaped the local flow field structure. Compared with concentric stenosis, eccentric models exhibited unique biomechanical instability due to the jet deflection effect. Specifically, the 50% proximal eccentric stenosis model showed the highest area fraction (0.17%) of regions with co-localized high OSI and high RRT. The 65% proximal eccentric model exhibited the highest area fraction (1.46%) of low TAWSS regions upstream and downstream of the stenosis, and its wall VMS peak was the highest (14.71 kPa), demonstrating distinct stress concentration. Conclusion The eccentric geometric feature of coronary stenosis is a key factor in reshaping the local flow field and stress distribution. Proximal severe eccentric stenosis encounters dual biomechanical risks: downstream lesion progression and plaque rupture at the stenotic throat. Therefore, biomechanical analysis incorporating geometric configurations can provide essential supplementary information for coronary risk stratification.
Last Update: 2026-07-23