Abstract

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Title:: Vascular stiffness investigation based on bioimpedance spectroscopy and pulse wave velocity analysis

Author(s):: ZHENG Changxin1; XU Wenzhu1; LIU Xianhong1; LIU Guoping1; MAO Shiqing1; WEI Wenying1; ZHU Yanzhou2; 1. Department of Nephrology-Hemodialysis, Mindong Hospital of Ningde City/Mindong Hospital Affiliated to Fujian Medical University, Ningde 355000, China 2. Department of Gerontology, Mindong Hospital of Ningde City/Mindong Hospital Affiliated to Fujian Medical University, Ningde 355000, China

Keywords:: Keywords: hemodialysis bioimpedance pulse wave velocity volume load vascular stiffness

Abstract:: linear regression analysis identified age, ECW/TBW, systolic blood pressure, and dialysis vintage as independent risk factors for baPWV in hemodialysis patients (P<0.05). Restricted cubic spline analysis indicated a non-linear relationship between ECW/TBW and baPWV (P<0.05). Compared with low baPWV subgroup, high baPWV subgroup had a higher incidence of cardiovascular disease (P<0.05), and shorter event-free survival time (P<0.05). Conclusion Hemodialysis can effectively reduce the volume load and vascular stiffness, but the vascular stiffness increases with longer dialysis vintage. The volume load of hemodialysis patients is closely associated with vascular stiffness in hemodialysis patients. ECW/TBW has a non-linear positive correlation with baPWV. Age, ECW/TBW, systolic blood pressure, and dialysis vintage are independent risk factors for vascular stiffness.