Dosimetric comparison of Edge-VMAT, Halcyon-VMAT, and HyperArc plans for hippocampal-sparing prophylactic cranial irradiation(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2026年第2期
- Page:
- 141-147
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Dosimetric comparison of Edge-VMAT, Halcyon-VMAT, and HyperArc plans for hippocampal-sparing prophylactic cranial irradiation
- Author(s):
- WANG Meijiao; LIU Jiacheng; YAO Kaining; PU Yichen; ZHANG Jian; LIU Zhuolun; DU Yi
- Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing)/Department of Radiotherapy, Peking University Cancer Hospital & Institute, Beijing 100142, China
- Keywords:
- Keywords: HyperArc Halcyon hippocampal-sparing prophylactic cranial irradiation volumetric-modulated arc?herapy
- PACS:
- R318；R811.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2026.02.001
- Abstract:
- Abstract: Objective To establish a standardized and high-quality planning template for hippocampal-sparing prophylactic cranial irradiation (HS-PCI) by quantifying the dosimetric differences among 3 treatment planning methods and conducting multidimensional dosimetric analysis and treatment efficiency evaluation, thereby improving the planning quality and clinical efficiency. Methods Twenty HS-PCI patients were enrolled, with 3 treatment plans, namely Edge-VMAT, Halcyon-VMAT, and HyperArc, designed for each patient. The differences in target dose, organs-at-risk dose, and machine units were compared among the 3 plans. Results The HyperArc plans exhibited significantly higher PTV D98% and V95 % than the Edge-VMAT plans and the Halcyon-VMAT plans (P<0.05). Although the HyperArc plans yielded the highest PTV Dmean, the differences among the 3 plans were trivial (P>0.05) and the lowest PTV Dmax was observed in the Edge-VMAT plans, but the differences across the 3 plans were also statistically insignificant (P>0.05). For PTV Dmin, the Halcyon-VMAT plans had the highest dose, with significant differences as compared with the other two plans (P<0.05). The PTV D2% in the Edge-VMAT plans was significantly lower than those in the other two plans (P<0.05). Plan quality evaluation showed that HyperArc plans achieved the highest conformity index and the lowest homogeneity index, both of which were significantly superior to those of the other two plans (P<0.05). The median hippocampal Dmax was 17 Gy for all 3 radiotherapy plans, with a statistically significant difference observed between the HyperArc plans and Halcyon-VMAT plans (P<0.05). For hippocampal Dmean and Dmin, the HyperArc plans had the lowest dose, and statistically significant differences were noted between the Edge-VMAT plans and Halcyon-VMAT plans, as well as between the Halcyon-VMAT plans and HyperArc plans (P<0.05). There were statistically significant differences among the 3 techniques in the Dmax of the left and right lens, left optic nerve and optic chiasm, as well as the Dmean of the left and right eyeballs (P<0.05). Conclusion HyperArc plan can be served as an effective treatment option for HS-PCI for it achieves superior target conformity and coverage while significantly reducing the dose to organs-at-risk.
Last Update: 2026-01-27