Altered patterns of interhemispheric functional connectivity in the cerebral cortex connected via the corpus callosum in Alzheimers disease(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2025年第11期
- Page:
- 1434-1444
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Altered patterns of interhemispheric functional connectivity in the cerebral cortex connected via the corpus callosum in Alzheimers disease
- Author(s):
- LI Zheyu1; 2; SHEN Yifan1; 2; LI Renren3; 4; PAN Chenxi3; 4; ZHANG Wei3; 4; XU Zhihao1; 2; YU Qiurong5; 6; YIN Dazhi7; 8; FAN Mingxia1; 2; LI Yunxia3; 4; NING Ruipeng1; 2
- 1. Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, China 2. Institute of Magnetic Resonance and Molecular Imaging in Medicine, East China Normal University, Shanghai 200062, China 3. Department of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China 4. Department of Neurology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, China 5. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 6. College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 7. School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China 8. Shanghai Changning Mental Health Center, Shanghai 200335, China
- Keywords:
- Keywords: Alzheimers disease mild cognitive impairment dementia corpus callosum resting-state functional magnetic resonance imaging functional connectivity
- PACS:
- R318；R749.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2025.11.005
- Abstract:
- Abstract: Objective To investigate alterations in interhemispheric functional connectivity (FC) in the cerebral cortices connected via the corpus callosum in patients with Alzheimers disease (AD), and to explore their relationships with cognitive function and activities of daily living. Methods Resting-state functional magnetic resonance imaging data were collected from 28 patients with Alzheimers dementia (d-AD), 47 patients with mild cognitive impairment (MCI), and 37 healthy controls (HC). Using a trancallosal tract template, 32 pairs of homologous cortical brain regions directly connected to 32 subregions of the corpus callosum were selected as regions of interest for interhemispheric FC analysis. Further correlation analyses were performed between FC values in patient groups and their scores on the Montreal Cognitive Assessment-Basic (MoCA-B) Scale and the Activities of Daily Living (ADL) Scale. Results Compared with HC group, both MCI and d-AD groups exhibited hyperconnectivity (significantly increased FC) in interhemispheric non-homologous brain regions. Specifically, hyperconnectivity in the MCI group was scattered across the frontal, parietal, temporal, and occipital lobes, while in the d-AD group, it was concentrated within the precentral and postcentral gyri. Notably, hyperconnectivity involving the prefrontal and occipital lobes in the MCI group showed significant declines in the d-AD group. The interhemispheric homologous FC in the d-AD group reduced more significantly than the MCI group. Additionally, in the d-AD group, 2 interhemispheric FC within the prefrontal lobe (between the bilateral orbital parts of the inferior frontal gyrus, and between the left medial frontal gyrus and the right middle frontal gyrus) were correlated with MoCA-B scores, and 2 FC (between the bilateral middle occipital gyri, and between the left inferior parietal lobule and the right middle frontal gyrus) were correlated with ADL scores. Conclusion MCI and d-AD exhibit distinct patterns of interhemispheric FC alterations, and the interhemispheric FC changes in AD patients are non-progressive. The close relationships between interhemispheric homologous/non-homologous FC and MoCA-B/ADL scores in d-AD patients provide an objective basis and reference for clinical neuromodulation.
Last Update: 2025-12-01