Fabrication and research of gelatin-based tissue mimicking material phantom with wall-less blood vessels for ultrasound applications(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2025年第11期
- Page:
- 1507-1513
- Research Field:
- 生物材料与力学
- Publishing date:
Info
- Title:
- Fabrication and research of gelatin-based tissue mimicking material phantom with wall-less blood vessels for ultrasound applications
- Author(s):
- LI Hongwei1; 2; 3; 4; WU Peikai5; XU Zixu4; NI Xinye1; 2
- 1. Department of Radiation Oncology, Changzhou No.2 Peoples Hospital of Nanjing Medical University, Changzhou 213003, China
2. Jiangsu Province Engineering Research Center of Medical Physics/Medical Physics Research Center of Nanjing Medical University/Key Laboratory of Medical Physics in Changzhou, Changzhou 213003, China 3. Radiotherapy Center, Peoples Hospital of Tongjiang County, Bazhong 636700, China 4. Radiotherapy Center, Sichuan Cancer Hospital, Chengdu 610041, China 5. Department of Radiation, Heyou International Health System, Foshan 528306, China
- Keywords:
- Keywords: Doppler ultrasound tissue mimicking material hemodynamic parameter blood mimicking fluid
- PACS:
- R312；R318
- DOI:
- DOI:10.3969/j.issn.1005-202X.2025.11.016
- Abstract:
- Abstract: Objective To fabricate wall-less vascular tissue mimicking materials (TMM) with different tube diameters that match the hemodynamic parameters of human carotid arteries, and to investigate their hemodynamic characteristics. Methods TMM with different diameters and blood mimicking fluids containing scattering particles were fabricated. The variation laws of hemodynamic parameters under different flow velocities and TMM phantom diameters were verified. Key hemodynamic parameters including peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistance index were measured using Doppler ultrasound, and their clinical application value in carotid artery diseases was evaluated. Results The fabricated samples exhibited a sound velocity of (1 506.2±0.1) m/s and an attenuation of (0.76±0.01) dB/cm, and the vascular diameters were 4.0 and 6.0 mm, which corresponded to the normal clinical range of the external and internal carotid arteries, respectively. For the 4.0 mm TMM, both PSV and EDV were linearly correlated with flow velocity (R2=0.77, P<0.001 R2=0.74, P=0.001), and Pearson correlation analysis confirmed strong positive correlations (r=0.89, 95%CI: 0.82-0.93 r=0.94, 95%CI: 0.90-0.97, all P<0.001). For the 6.0 mm TMM, PSV and EDV also demonstrated significant linear correlations with flow velocity (R2=0.70, P=0.001 R2=0.61, P=0.005), with Pearson correlation analysis revealing strong positive correlations (r=0.86, 95%CI: 0.78-0.91 r=0.79, 95%CI: 0.68-0.87). All the data were consistent with hemodynamic parameters and followed the variation law of hemodynamic parameters. Conclusion The fabricated TMM and blood mimicking fluids meet the requirements for clinical ultrasound research on hemodynamics, and their material ratios can be used as a reference for the subsequent researches with diverse objectives.
Last Update: 2025-12-01